Morphological and biochemical effects of a low ethanol dose on rat liver regeneration -: Role of route and timing of administration
Morphological and biochemical effects of a low ethanol dose on rat liver regeneration -: Role of route and timing of administration
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DOI：
10.1023/a:1026601814082
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发表时间：
1999-10-01
影响因子：
3.1
通讯作者：
Hernández-Muñoz, R
中科院分区：
文献类型：
--
作者：
Morales-González, JA;Gutiérrez-Salinas, J;Hernández-Muñoz, R
我们已经证明，在接受部分肝切除术（PH）的大鼠中，再生的肝脏具有增强的乙醇代谢，这在很大程度上取决于乙醇给药的途径和时间。因此，在70%PH的动物中评价了给药途径和时间对乙醇诱导的对再生大鼠肝脏的有害作用的影响。残留肝脏显示中度脂肪浸润、肝细胞结构的扩展扭曲和高有丝分裂指数。乙醇灌胃给药（1.5 g/kg体重）显著降低了PH诱导的肝脏结构变化。乙醇处理还降低了肝脏胸苷激酶活性、血清白蛋白和葡萄糖水平。PH大鼠腹腔注射相同剂量的乙醇对肝再生的影响较小。独立的给药途径，乙醇突然缩短PH诱导的选择性增加血清酶活性。这些数据表明，低剂量乙醇对PH诱导的肝再生的抑制作用依赖于给药的时间和途径。
We have demonstrated that in rats subjected to partial hepatectomy (PH), the regenerating liver had an enhanced metabolism of ethanol, which largely depended on the route and timing of ethanol administration. Therefore, the influence of the administration route and timing for ethanol-induced deleterious effects on the regenerating rat liver was evaluated in animals subjected to 70% PH. Remnant liver showed moderate fatty infiltration, extended distortion of hepatocellular structure, and high mitotic index. Intragastric ethanol administration (1.5 g/kg body weight) considerably reduced the PH-induced changes in liver structures. Ethanol treatment also decreased liver thymidine kinase activity, serum albumin, and glucose levels. Intraperitoneal administration of the same ethanol dose to PH rats promoted lesser alterations on liver regeneration. Independently of its administration route, ethanol abruptly shortened a PH-induced selective increase in serum enzyme activities. These data suggest that the inhibitory effect of a low dose of ethanol on PH-induced liver regeneration is dependent on the timing and route of administration.