Synthesis of tissues and organs.
Synthesis of tissues and organs.
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组织和器官的合成。
DOI：
10.1002/cbic.200300682
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Yannas,IoannisV
中科院分区：
文献类型：
--
作者：
Yannas,IoannisV
描述化合物合成过程的符号学，已经被用来定性地描述在正确的解剖位置上组织和器官的合成。反应图是反应物、反应器和产物的简略表示，它概括了合成过程。大量的独立协议的分析，导致识别的最简单的合成途径的两个器官，已被广泛研究：皮肤和外周神经。这两个器官的这些显然不可简化的反应图不仅简单，而且惊人地相似，这一事实表明，其他器官的合成也存在一般规则。唯一需要的两种反应物是活性支架（作为细胞外基质的高度多孔类似物合成的大分子网络）和正在合成的器官的上皮细胞的接种。支架具有生物（再生）活性，前提是它们能够阻断导致损伤部位闭合的收缩过程。这种活性要求用于结合支架上的收缩细胞的配体密度在合成期间保持足够高的水平。
Symbolism that describes the synthetic processes for chemical compounds has been used to describe, in qualitative terms, the synthesis of tissues and organs at the correct anatomical site. The synthetic process is summarized in the reaction diagram, a shorthand representation of the reactants, reactor, and products. Analysis of a large number of independent protocols has led to identification of the simplest synthetic pathways for two organs that have been studied extensively: skin and peripheral nerves. These apparently irreducible reaction diagrams for the two organs are not only simple but surprisingly similar, a fact suggesting the existence of general rules for the synthesis of other organs as well. The only two reactants that are required are an active scaffold (a macromolecular network synthesized as a highly porous analogue of the extracellular matrix) and a seeding of epithelial cells of the organ being synthesized. Scaffolds possessed biological (regenerative) activity provided that they were capable of blocking the contraction process that leads to closure of the injured site. Such activity requires that the density of ligands for binding of contractile cells on the scaffold maintains a sufficiently high level over the period of synthesis.