P-glycoprotein and bilirubin disposition.
P-glycoprotein and bilirubin disposition.
复制标题
P-糖蛋白和胆红素的分布。
DOI：
10.1038/sj.jp.7210633
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Ahdab-Barmada,M
中科院分区：
文献类型：
--
作者：
Watchko,JF;Daood,MJ;Mahmood,B;Vats,K;Hart,C;Ahdab-Barmada,M
P-glycoprotein (Pgp), an ATP-dependent plasma membrane efflux pump, is expressed in abundance on the luminal aspect of brain capillary endothelial cells and astrocytes of the blood–brain barrier where it limits the passage of a variety of lipophilic substrates into the central nervous system. This review summarizes current evidence characterizing (1) unconjugated bilirubin as a potential substrate for Pgp and (2) the ontogeny of Pgp expression at the blood–brain barrier and apical brush border epithelium of the gastrointestinal tract, findings that may provide insights regarding the disposition of bilirubin in immature subjects.
