Body Composition and Diabetes Risk in South Asians: Findings From the MASALA and MESA Studies
Body Composition and Diabetes Risk in South Asians: Findings From the MASALA and MESA Studies
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DOI：
10.2337/dc18-1510
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发表时间：
2019-05-01
期刊：
影响因子：
16.2
通讯作者：
Kanaya, Alka M.
中科院分区：
文献类型：
--
作者：
Flowers, Elena;Lin, Feng;Kanaya, Alka M.
目的与其他种族/民族相比，南亚人2型糖尿病的患病率较高。身体成分与患2型糖尿病的风险有关。南亚人和其他种族/民族之间的身体成分差异是解释这一人群中不成比例的2型糖尿病患病率的一个假设机制。研究设计与方法这项研究使用了居住在美国的南亚人动脉粥样硬化的介体(Masala)和多种族动脉粥样硬化研究(MESA)队列的数据，以确定身体成分是否导致南亚人空腹血糖受损和2型糖尿病患病率的增加。有完整身体成分数据的参与者(n=2,615)包括在内。计算有序Logistic回归模型，以确定南亚人与MESA队列相比的血糖损害的几率。结果在多变量模型中，南亚人的血糖受损和2型糖尿病的患病率显著高于梅萨地区所有四个种族/民族(P<；0.001)。在未经调整和多变量调整的模型中，与所有其他种族/民族相比，南亚人患空腹血糖受损和2型糖尿病的几率更高(P<；0.001)。身体成分测量的增加并没有显著缓解这种关系。结论：我们没有找到强有力的证据来说明身体成分可以解释2型糖尿病风险的差异。未来需要对Mesa和Masala队列进行前瞻性研究，以了解脂肪组织如何影响2型糖尿病的风险，以及如何最好地评估这种风险。
OBJECTIVE South Asians have a higher prevalence of type 2 diabetes compared with other race/ethnic groups. Body composition is associated with the risk for type 2 diabetes. Differences in body composition between South Asians and other race/ethnic groups are one hypothesized mechanism to explain the disproportionate prevalence of type 2 diabetes in this population. RESEARCH DESIGN AND METHODS This study used data from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) and the Multi-Ethnic Study of Atherosclerosis (MESA) cohorts to determine whether body composition mediated the elevated prevalence of impaired fasting glucose and type 2 diabetes in South Asians. Participants (n = 2,615) with complete body composition data were included. Ordinal logistic regression models were calculated to determine the odds for glycemic impairment in South Asians compared with the MESA cohort. RESULTS In multivariate models, South Asians had a significantly higher prevalence of glycemic impairment and type 2 diabetes compared with all four race/ethnic groups included in the MESA (P < 0.001 for all). In unadjusted and multivariate adjusted models, South Asians had higher odds for impaired fasting glucose and type 2 diabetes compared with all other race/ethnic groups (P < 0.001 for all). The addition of body composition measures did not significantly mitigate this relationship. CONCLUSIONS We did not identify strong evidence that accounting for body composition explains differences in the risk for type 2 diabetes. Future prospective studies of the MESA and MASALA cohorts are needed to understand how adipose tissue impacts the risk for type 2 diabetes and how to best assess this risk.