Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice
Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice
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DOI：
10.1038/nnano.2016.88
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发表时间：
2016-09-01
影响因子：
38.3
通讯作者：
Tsutsumi, Yasuo
中科院分区：
文献类型：
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作者：
Hirai, Toshiro;Yoshioka, Yasuo;Tsutsumi, Yasuo
许多人患有金属过敏，最近在我们的环境中自然存在的金属纳米颗粒可能是诱发金属过敏的新候选物。在这里，我们展示了用纳米银粒子（nAg）和脂多糖预处理的小鼠，而不是用被认为会引起过敏的银离子预处理的小鼠，对银的反应产生了过敏性炎症。nag诱导的获得性免疫反应依赖于CD4(+) T细胞，并引发il - 17a介导的炎症，类似于在人类金属过敏中观察到的情况。镍纳米颗粒也会引起小鼠的致敏，而金纳米颗粒和二氧化硅纳米颗粒则不会。定量分析银的分布提示小nAg （10 nm）。这些结果表明，金属纳米颗粒可以作为离子载体实现金属敏化。我们的数据显示了金属过敏的潜在新诱因。
Many people suffer from metal allergy, and the recently demonstrated presence of naturally occurring metal nanoparticles in our environment could present a new candidate for inducing metal allergy. Here, we show that mice pretreated with silver nanoparticles (nAg) and lipopolysaccharides, but not with the silver ions that are thought to cause allergies, developed allergic inflammation in response to the silver. nAg-induced acquired immune responses depended on CD4(+) T cells and elicited IL-17A-mediated inflammation, similar to that observed in human metal allergy. Nickel nanoparticles also caused sensitization in the mice, whereas gold and silica nanoparticles, which are minimally ionizable, did not. Quantitative analysis of the silver distribution suggested that small nAg (10 nm). These results suggest that metal nanoparticles served as ion carriers to enable metal sensitization. Our data demonstrate a potentially new trigger for metal allergy.