Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle
Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle
复制标题
DOI：
10.1073/pnas.93.12.6209
复制
发表时间：
1996-06-11
影响因子：
11.1
通讯作者：
Persing, DH
中科院分区：
文献类型：
--
作者：
Telford, SR;Dawson, JE;Persing, DH
人粒细胞埃立克体病（一种最近描述的新出现的立克次体病）的病原体的人源菌株已经通过在小鼠宿主中连续血液传代而建立，幼鹿蜱通过进食这些小鼠获得感染，并在蜕皮后有效地将埃立克体传播给鹿，从而证明了载体能力，通过实验感染的蜱和来自野外的成年鹿蜱的唾液腺中展示Feulgen阳性内含物来检测该药剂。来自野外的白足小鼠感染了实验室饲养的人粒细胞埃立克体病病原体蜱，这表明这些啮齿动物是埃立克体、莱姆病螺旋体和导致人类巴贝虫病的梨形虫的宿主。大约10%的寻找宿主的鹿蜱感染了埃立克体，其中20%还含有螺旋体。在某些地方性流行地区，由积极咬人的鹿蜱引起的多种病原体的共传播可能对公共卫生产生独特的影响。
A human-derived strain of the agent of human granulocytic ehrlichiosis, a recently described emerging rickettsial disease, has been established by serial blood passage in mouse hosts, Larval deer ticks acquired infection by feeding upon such mice and efficiently transmitted the ehrlichiae after molting to nymphs, thereby demonstrating vector competence, The agent was detected hy demonstrating Feulgen-positive inclusions in the salivary glands of the experimentally infected ticks and from field-derived adult deer ticks. White-footed mice from a field site infected laboratory-reared ticks with the agent of human granulocytic ehrlichiosis, suggesting that these rodents serve as reservoirs for ehrlichiae as well as for Lyme disease spirochetes and the piroplasm that causes human babesiosis. About 10% of host-seeking deer ticks were infected with ehrlichiae, and of these, 20% also contained spirochetes. Cotransmission of diverse pathogens by the aggressively human-biting deer tick may have a unique impact on public health in certain endemic sites.