TMPRSS3 is a novel poor prognostic factor for breast cancer.
TMPRSS3 is a novel poor prognostic factor for breast cancer.
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TMPRSS3 是一种新的乳腺癌不良预后因素。
DOI：
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发表时间：
2015
影响因子：
1.4
通讯作者：
Feng Li
中科院分区：
文献类型：
--
作者：
Xue Rui;Yanshu Li;F. Jin;Feng Li
最近有报道称跨膜蛋白酶丝氨酸3 (TMPRSS3) 在癌症中过度表达。然而，TMPRSS3在乳腺癌（BC）中的表达及其生物学作用尚未见报道。本研究旨在探讨BC中TMPRSS3的表达及其与BC结果的关系。本研究共涉及 2004 年至 2007 年间诊断的 149 个 BC 组织和邻近非癌组织。免疫组织化学用于比较 BC 和邻近非癌组织中 TMPRSS3 的表达模式。 Kaplan-Meier 和 Cox 回归分析用于评估 BC 患者中 TMPRSS3 表达的预后意义。结果如下：与邻近非癌组织相比，BC中TMPRSS3表达显着。 TMPRSS3 高表达与 TNM 分期、淋巴结转移和 Ki-67 表达相关。此外，TMPRSS3 高表达的 BC 患者的总生存期 (OS) 和无病生存期 (DFS) 低于 TMPRSS3 低表达的患者。基于多因素分析，淋巴结转移、TNM分期和TMPRSS3表达是BC中OS的独立预后因素，而淋巴结转移和TMPRSS3表达是BC中DFS的独立预后因素。本研究证明TMPRSS3表达是BC患者的独立预后因素。对潜在 TMPRSS3 结合蛋白的生物信息分析表明，TMPRSS3 可能是癌症途径的关键调节因子。这项研究有助于我们更好地了解 TMPRSS3 在癌症中的功能。
It has recently been reported that transmembrane protease, serine 3 (TMPRSS3) is overexpressed in cancer. However, TMPRSS3 expression and its biological roles in breast cancer (BC) have not been reported. This study aims to investigate the TMPRSS3 expression in BC and its relation with the outcome of the BC. This study involves a total of 149 BC tissues and adjacent non-cancerous tissues that were diagnosed between 2004 and 2007. Immunohistochemistry is used to compare the pattern of TMPRSS3 expression in BC and in adjacent non-cancerous tissues. Kaplan-Meier and Cox regression analyses were used to assess the prognostic significance of TMPRSS3 expression among BC patients. The results are as follow: TMPRSS3 expression is significantly in BC compared to adjacent non-cancerous tissues. High TMPRSS3 expression was related to TNM stage, lymph node metastasis, and Ki-67 expression. Furthermore, the overall survival (OS) and disease-free survival (DFS) in BC patients with high TMPRSS3 expression were lower than those in patients with low TMPRSS3 expression. Based on multivariate analysis, lymph node metastasis, TNM stage and TMPRSS3 expression are independent prognostic factors for OS in BC, while lymph node metastasis and TMPRSS3 expression are independent prognostic factors for DFS in BC. This study proves that TMPRSS3 expression is an independent prognostic factor for BC patients. Bioinformatic analysis of potential TMPRSS3 binding proteins revealed that TMPRSS3 could be a key regulator of cancer pathways. This study helps us better understand the function of TMPRSS3 in cancer.
影响因子：
11.2
作者：
C. Iacobuzio-Donahue;R. Ashfaq;A. Maitra;N. Adsay;G. Shen-Ong;K. Berg;M. Hollingsworth;J. Cameron;C. Yeo;S. Kern;M. Goggins;R. Hruban
通讯作者：
C. Iacobuzio-Donahue;R. Ashfaq;A. Maitra;N. Adsay;G. Shen-Ong;K. Berg;M. Hollingsworth;J. Cameron;C. Yeo;S. Kern;M. Goggins;R. Hruban
通过转录谱的荟萃分析评估 FBXW7 表达水平在人类乳腺癌中的预后意义。
DOI：
10.4172/1948-5956.1000158
发表时间：
2012
期刊：
Journal of cancer science & therapy
影响因子：
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作者：
Wei,Guangwei;Wang,Yunshan;Zhang,Pengju;Lu,Jing;Mao,Jian-Hua
通讯作者：
Mao,Jian-Hua