Recent advances in copper-catalyzed C-N bond formation involving N-centered radicals.
Recent advances in copper-catalyzed C-N bond formation involving N-centered radicals.
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DOI：
10.1002/cssc.202102243
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发表时间：
2021-11
期刊：
影响因子：
8.4
通讯作者：
Yan-Nan Zheng;Hongxing Zheng;Ting Li;Wen‐Ting Wei
中科院分区：
文献类型：
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作者：
Yan-Nan Zheng;Hongxing Zheng;Ting Li;Wen‐Ting Wei
C-N键普遍存在于有机基材料、天然产物、药物化合物和农业化学品中。考虑到C-N键的广泛重要性，开发更绿色、更方便的C-N键形成方法，特别是在后期合成中，已成为合成化学中最热门的研究目标之一。涉及N中心自由基的铜催化自由基反应已经成为构建C-N键的可持续和有前途的方法。N -中心自由基作为一种化学上广泛存在的自由基，由于其本身所具有的反应灵活性，已经被用于各种C-N键的形成反应。铜也是最丰富和最经济的催化剂，具有促进有价值化合物合成的最相关活性。因此，本综述的目的是说明C-N键形成方法的最新重大进展，并了解自2016年以来铜催化在产生N中心自由基方面的独特优势。
C-N bonds are pervasive throughout organic-based materials, natural products, pharmaceutical compounds, and agricultural chemicals. Considering the widespread importance of C-N bonds, the development of greener and more convenient ways to form C-N bonds, especially in late-stage synthesis, has become one of the hottest research goals in synthetic chemistry. Copper-catalyzed radical reactions involving N -centered radicals have emerged as a sustainable and promising approach to build C-N bonds. As the chemically popular and diverse radical, N -centered radicals have been treated with all kinds of reactions for the C-N bonds formation by taking advantage of their inherently incredible reactive flexibility. Copper is also the most abundant and economy catalyst with the most relevant activity for facilitating the synthesis of valuable compounds. Therefore, the aim of the present review is to illustrate recent and significant advances in C-N bond formation methods and understand the unique advantages of copper catalysis in the generation of N -centered radicals since 2016.