One pot synthesis of zwitteronic 99mTc doped ultrasmall iron oxide nanoparticles for SPECT/T1-weighted MR dual-modality tumor imaging
One pot synthesis of zwitteronic 99mTc doped ultrasmall iron oxide nanoparticles for SPECT/T1-weighted MR dual-modality tumor imaging
复制标题
用于 SPECT/T1 加权 MR 双模态肿瘤成像的两性 99mTc 掺杂超小氧化铁纳米颗粒的一锅法合成
DOI：
10.1016/j.colsurfb.2020.111403
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Sun xiaolian
中科院分区：
文献类型：
--
作者：
Wang peng;Sun Wenjing;Guo Jingru;Zhang kaijia;Liu Yi;Jiang Qing;Su Dan;Sun xiaolian
In this study, we have synthesized99mTc intrinsically labeled ultrasmall magnetic iron oxide nanoparticles with zwitterionic surface coating (99mTc-ZW-USIONPs)viaone pot synthesis using sulfobetains functionalized poly (acrylic acid) as stabilizer and Na99mTcO4and SnCl2as additives. The commercialization of single photon emission computed tomography (SPECT)/magnetic resonance imaging (MRI) scanner made the combination use of99mTc and iron oxide nanoparticles attracting much attention. Direct doping radioisotope into nanoparticles has the advantages of excellent radiochemical stability and no restriction on the surface functionalization. The complex Technetium chemistry made it challenging to direct dope99mTc into IONPs, especially those ultrasmall ones without precipitation. We proved that it is possible to prepare99mTc doped USIONPs with excellent water solubility and favorable T1 signal by controlling the radioactivity and reducing agent amount. With no need of chelator, the zwitterionic surface resists the protein corona formation, resulting in a reduced RES uptake and higher tumor contrast. The99mTc-ZW-USIONPs demonstrated excellent performance of tumor SPECT and T1-weighted MR imaging capability in 4T1 tumor bearing mice. Together with their ease of preparation and superior biocompatibility, we believe these99mTc-ZW-USIONPs represent a type of promising dual contrast agent for SPECT/T1 MRI.
