Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids.
Interactions with Microbial Proteins Driving the Antibacterial Activity of Flavonoids.
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与驱动类黄酮抗菌活性的微生物蛋白相互作用。
DOI：
10.3390/pharmaceutics13050660
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发表时间：
2021-05-05
期刊：
影响因子：
5.4
通讯作者：
Dal Piaz F
中科院分区：
文献类型：
--
作者：
Donadio G;Mensitieri F;Santoro V;Parisi V;Bellone ML;De Tommasi N;Izzo V;Dal Piaz F
黄酮类化合物是由植物产生的最丰富的天然生物活性化合物之一。已经报道了这些次级代谢产物对许多细胞和系统的许多不同活性。其中最有趣的当然是抗菌剂，它通过各种分子机制刺激。事实上，类黄酮不仅能直接破坏革兰氏阴性和革兰氏阳性细菌的包膜，而且还能作用于这些微生物生存所必需的特定分子靶标。本文的目的是提出一个概述的最有趣的结果，在研究中获得的主要集中在黄酮类化合物和细菌蛋白质之间的相互作用的研究。尽管这些植物代谢产物的结构具有很大的异质性，但有趣的是观察到许多类黄酮影响相同的细胞途径。此外，很明显，这些化合物中的一些与一个以上的目标相互作用，产生多种效果。总之，报告的数据表明类黄酮在开发创新系统方面具有巨大潜力，这有助于解决日益严重的抗生素耐药性问题。
Flavonoids are among the most abundant natural bioactive compounds produced by plants. Many different activities have been reported for these secondary metabolites against numerous cells and systems. One of the most interesting is certainly the antimicrobial, which is stimulated through various molecular mechanisms. In fact, flavonoids are effective both in directly damaging the envelope of Gram-negative and Gram-positive bacteria but also by acting toward specific molecular targets essential for the survival of these microorganisms. The purpose of this paper is to present an overview of the most interesting results obtained in the research focused on the study of the interactions between flavonoids and bacterial proteins. Despite the great structural heterogeneity of these plant metabolites, it is interesting to observe that many flavonoids affect the same cellular pathways. Furthermore, it is evident that some of these compounds interact with more than one target, producing multiple effects. Taken together, the reported data demonstrate the great potential of flavonoids in developing innovative systems, which can help address the increasingly serious problem of antibiotic resistance.