Memory consolidation during sleep - Role of cortisol feedback
Memory consolidation during sleep - Role of cortisol feedback
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DOI：
10.1196/annals.1314.020
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Wagner, U
中科院分区：
文献类型：
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作者：
Born, J;Wagner, U
人类夜间皮质醇的释放受到昼夜节律和睡眠的协同调节。皮质醇浓度通常在早期夜间睡眠的慢波睡眠丰富期达到最低点，而在深夜，当快速眼动 (REM) 睡眠占主导地位时，皮质醇水平会升高。在这里，我们回顾了我们自己的一系列研究，研究了皮质醇释放的调节是否以及如何影响睡眠期间记忆的巩固。研究表明，在早期慢波睡眠丰富的夜间睡眠期间，皮质醇的增加会损害海马体依赖性陈述性记忆的形成。在深夜快速眼动睡眠期间防止皮质醇自然增加似乎可以增强杏仁核依赖性的情绪记忆。这些发现与皮质醇通过激活边缘糖皮质激素受体通常会削弱记忆巩固的观点是一致的。
Nocturnal cortisol release in humans is synergistically regulated by circadian rhythm and sleep. Cortisol concentrations typically reach a nadir during the slow wave sleep-rich periods of early nocturnal sleep, whereas during the late night, when rapid eye movement (REM) sleep predominates, cortisol levels are enhanced. Here we review a series of our own studies examining whether and how this regulation of cortisol release affects the consolidation of memories during sleep. The studies show that increasing cortisol during early slow wave sleep-rich periods of nocturnal sleep impairs hippocampus-dependent declarative memory formation. Preventing the natural increase in cortisol during REM sleep-rich sleep in the late night appears to enhance amygdala-dependent emotional memory. The findings are consistent with the view that cortisol via activation of limbic glucocorticoid receptors generally diminishes memory consolidation.