G-protein Coupled Receptor Signaling in Pluripotent Stem Cell-derived Cardiovascular Cells: Implications for Disease Modeling.
G-protein Coupled Receptor Signaling in Pluripotent Stem Cell-derived Cardiovascular Cells: Implications for Disease Modeling.
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DOI：
10.3389/fcell.2015.00076
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发表时间：
2015
影响因子：
5.5
通讯作者：
Földes G
中科院分区：
文献类型：
--
作者：
Dolatshad NF;Hellen N;Jabbour RJ;Harding SE;Földes G
人类多能干细胞衍生物显示出作为研究一系列人类心血管疾病的体外平台的前景。更好地理解干细胞及其心血管衍生物的生物学将有助于理解这种新模型系统的优势和局限性。G蛋白偶联受体（GPCR）是干细胞维持和分化的关键调节因子，在心血管细胞信号传导中发挥重要作用。因此，在这篇综述中，我们将描述有关GPCR在多能干细胞衍生的心肌细胞，内皮细胞和血管平滑肌细胞的生成和功能的调节作用的知识状态。我们将考虑体外疾病模型在多大程度上重现真实的GPCR信号传导，并为发现疾病机制或设计治疗策略提供有用的基础。
Human pluripotent stem cell derivatives show promise as an in vitro platform to study a range of human cardiovascular diseases. A better understanding of the biology of stem cells and their cardiovascular derivatives will help to understand the strengths and limitations of this new model system. G-protein coupled receptors (GPCRs) are key regulators of stem cell maintenance and differentiation and have an important role in cardiovascular cell signaling. In this review, we will therefore describe the state of knowledge concerning the regulatory role of GPCRs in both the generation and function of pluripotent stem cell derived-cardiomyocytes, -endothelial, and -vascular smooth muscle cells. We will consider how far the in vitro disease models recapitulate authentic GPCR signaling and provide a useful basis for discovery of disease mechanisms or design of therapeutic strategies.