Activity-dependent enhancement in the reliability of correlated spike timings in cultured cortical neurons
Activity-dependent enhancement in the reliability of correlated spike timings in cultured cortical neurons
复制标题
培养皮层神经元中相关尖峰计时可靠性的活动依赖性增强
作者：
T. Tateno;Y. Jimbo
抽象。为了研究神经网络中活动的使用依赖性修改，我们通过同时记录培养的皮层神经元网络中多个位点的活动来研究尖峰时间。我们使用动力学分析来研究的时间结构的锋电位列车和活动依赖性的变化，由刺激诱发的锋电位模式的可靠性和再现性。我们还使用互相关分析来评估神经元对的相互作用。我们的主要结论是，即使当没有明显的变化，尖峰数量可以看到，使用依赖性的修改发生，无论是增强或减少刺激诱发的尖峰列车的可靠性和再现性，和刺激诱发的尖峰列车和神经元之间的相互作用的精细的时间结构也修改强直刺激。
Abstract. To study the use-dependent modification of activity in neural networks, we investigated the spike timing by simultaneously recording activity at multiple sites in a network of cultured cortical neurons. We used dynamical analysis to study the temporal structure of spike trains and the activity-dependent changes in the reliability and reproducibility of spike patterns evoked by a stimulus. We also used cross-correlation analysis to evaluate the interactions of neuron pairs. Our main conclusions are that even when no obvious change in spike numbers can be seen, use-dependent modification occurs, either enhancing or reducing in the reliability and reproducibility of spike trains evoked by a stimulus, and the fine temporal structure of stimulus-evoked spike trains and interactions between neurons are also modified by tetanic stimulation.
影响因子：
2.5
作者：
LUHMANN, HJ;PRINCE, DA
通讯作者：
PRINCE, DA