IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice.
IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice.
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DOI：
10.4049/jimmunol.154.9.4675
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发表时间：
1995-05
影响因子：
4.4
通讯作者：
Joseph F Urban;C. Maliszewski;K. Madden;I. Katona;F. Finkelman
中科院分区：
文献类型：
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作者：
Joseph F Urban;C. Maliszewski;K. Madden;I. Katona;F. Finkelman
我们研究了长效 IL-4 制剂（IL-4/抗 IL-4 mAb 复合物）限制正常小鼠和免疫缺陷小鼠两种线虫寄生虫（Heligmosomoides polygyrus 和 Nippostrongylus brasiliensis）感染的能力。每 3 至 4 天使用 5 至 20 微克的 IL-4 会迅速降低产蛋量，并在 6 至 9 天的时间内终止接种 H. polygyrus 的 BALB/c 小鼠的感染。 IL-4 治疗还显着降低了 H. polygyrus 接种的 CB.17 严重联合免疫缺陷 (SCID) 小鼠的产卵量，并终止了接种巴西 N. brasiliensis 的 SCID 小鼠和抗 CD4 mAb 处理的 BALB/c 小鼠的感染。如果在寄生虫处于幼虫阶段时施用，则IL-4在限制H.polygyrus感染方面的效果不如在成虫发育后施用时有效。 IL-4 的作用可被特异性阻断小鼠 IL-4R 的 mAb 完全抑制。这些观察结果表明，IL-4 可以通过不依赖于特定免疫系统的对宿主的影响来限制胃肠道线虫寄生虫的繁殖力和生存。
We examined the ability of a long acting formulation of IL-4 (IL-4/anti-IL-4 mAb complexes) to limit established infections of normal and immune deficient mice with two nematode parasites: Heligmosomoides polygyrus and Nippostrongylus brasiliensis. IL-4, at a dose of 5 to 20 micrograms every 3 to 4 days, rapidly decreased egg production and, over a period of 6 to 9 days, terminated infection in H. polygyrus-inoculated BALB/c mice. IL-4 treatment also considerably decreased egg production in H. polygyrus-inoculated CB.17 severe combined immunodeficient (SCID) mice and terminated infection in N. brasiliensis-inoculated SCID mice and anti-CD4 mAb-treated BALB/c mice. IL-4 was less effective at limiting H. polygyrus infection if administrated when parasites were in larval stages than if administered after adult worms had developed. The effects of IL-4 were inhibited completely by an mAb that specifically blocks the mouse IL-4R. These observations demonstrate that IL-4 can limit the fecundity and survival of gastrointestinal nematode parasites through effects on the host that are independent of the specific immune system.