Androgen receptor functions in male and female physiology
Androgen receptor functions in male and female physiology
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DOI：
10.1016/j.jsbmb.2008.03.023
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发表时间：
2008-04
期刊：
影响因子：
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通讯作者：
Takahiro Matsumoto;Hiroko Shiina;H. Kawano;Takashi Sato;S. Kato
中科院分区：
文献类型：
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作者：
Takahiro Matsumoto;Hiroko Shiina;H. Kawano;Takashi Sato;S. Kato
雄激素的生物学作用是通过与雄激素受体（AR）结合而介导靶基因的转录控制。AR属于核受体超家族，作为配体诱导的转录因子。雄激素/AR系统被认为是男性生理和临床病理发展的核心行为。目前公认的AR功能在雌性生殖中的生理重要性也已在小鼠遗传模型中得到验证。本文综述了AR缺失小鼠在雄性和雌性生理上的功能。
The biological actions of androgens are mediated by transcriptional control of target genes through binding to the androgen receptor (AR). The AR belongs to the nuclear receptor superfamily and acts as a ligand-inducible transcriptional factor. Androgens/AR system is thought to be central to male physiology and behaviors to the development of clinical pathology. The physiological importance of AR function currently recognized in female reproduction also has been verified in mouse genetic model. Here we review functions of AR in male and female physiology as revealed by mice lacking AR.