Development of polymer field-effect transistor-based immunoassays
Development of polymer field-effect transistor-based immunoassays
复制标题
基于聚合物场效应晶体管的免疫分析的发展
DOI：
10.1038/s41428-018-0112-0
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发表时间：
2018
期刊：
影响因子：
2.8
通讯作者：
Tsuyoshi Minami
中科院分区：
文献类型：
--
作者：
Tsukuru Minamiki;Yui Sasaki;Shiwei Su;Tsuyoshi Minami
聚合物场效应晶体管（PFFET）是最具吸引力的电子器件之一，因为它们有吸引力的特性，如耐用性，环境友好性和溶液加工性。迄今为止，PFDs已被用于开发柔性显示器、射频识别标签、柔性非易失性存储器等。此外，由于上述优点，PFF4可应用于一次性现场分析装置。在这方面，我们已经开发了扩展门型PFQs与分子识别生物材料的蛋白质传感在水介质中。制造的PFFEs被用来成功地检测糖蛋白（免疫球蛋白A，免疫球蛋白G和嗜铬粒蛋白A），没有任何复杂的标记过程。由于我们提出的免疫分析，这是基于扩展栅型PFET进行的，是快速和易于使用，PFET将是一个有吸引力的平台，现场监测设备在不久的将来在医疗保健应用。
Polymer field-effect transistors (PFETs) are among the most fascinating electronic devices because of their attractive properties, such as durability, environmental friendliness, and solution processability. To date, PFETs have been employed for the development of flexible displays, radio-frequency identification tags, flexible non-volatile memories, among others. Moreover, due to the above advantages, PFETs can be applied to disposable on-site analytical devices. In that regard, we have developed extended-gate type PFETs with molecular recognition biomaterials for protein sensing in aqueous media. The fabricated PFETs were used to successfully detect glycoproteins (immunoglobulin A, immunoglobulin G, and chromogranin A) without any complicated labeling processes. Since our proposed immunoassay, which is performed on the basis of extended-gate type PFETs, is rapid and easy-to-use, PFET will be an attractive platform for on-site monitoring devices in healthcare applications in the near future.