Developmental modification of the Drosophila cell cycle.
Developmental modification of the Drosophila cell cycle.
复制标题
果蝇细胞周期的发育修饰。
DOI：
10.1016/0168-9525(94)90035-3
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Orr-Weaver,TL
中科院分区：
文献类型：
--
作者：
Orr-Weaver,TL
细胞周期受外部调节，协调细胞分裂与发育事件。这一重要领域是发育生物学和细胞周期研究的交叉领域，最近取得了令人兴奋的进展。细胞周期的发育修饰在果蝇胚胎发生过程中得到了例证。在胚胎发生早期，细胞周期的调节逐渐变得复杂，因为简单的S-M周期被改变为包括间隙期。在胚胎发生的后期，周期再次改变，只包括一个S期和一个间隙期。这些发育改变部分是通过调节控制细胞周期关键转变的基因表达来实现的。还定义了变异细胞周期特有的某些控制。该领域现在准备鉴定发育信号和它们对已知细胞周期调节因子的最终影响之间的干预步骤。
The cell cycle is subject to extrinsic regulation that coordinates cell division with developmental events. This important area at the interface of developmental biology and research into the cell cycle has yielded recent exciting advances. Developmental modification of the cell cycle is exemplified duringDrosophilaembryogenesis. Early in embryogenesis, regulation of the cell cycle becomes progressively more complex as a simple S-M cycle is altered to include gap phases. Later in embryogenesis, the cycle alters again, to include only an S and a gap phase. These developmental alterations are partly effected by regulating the expression of genes that control key transitions in the cell cycle. Certain controls that are unique to the variant cell cycles have also been defined. The field is now poised for the identification of the intervening steps between the developmental signals and their ultimate effects on known cell cycle regulators.