Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo
Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo
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DOI：
10.1158/1055-9965.epi-07-0152
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发表时间：
2007-07-01
影响因子：
3.8
通讯作者：
Spector, Tim D.
中科院分区：
文献类型：
--
作者：
Bataille, Veronique;Kato, Bernet S.;Spector, Tim D.
痣计数是黑色素瘤最强的风险因素之一。它们出现在童年和青春期，从中年开始逐渐发展。最近的证据表明，痣细胞经历癌基因诱导的衰老涉及p16/视网膜母细胞瘤途径。然而，端粒长度也影响增殖体细胞的衰老，并且个体之间存在差异。这项研究探讨了在白色细胞中测量的端粒长度是否与1,897名年龄在18至79岁的白人女性的痣数量和大小相关。校正年龄后，全身痣计数与白色细胞端粒长度（平均值，7.09 kbp;范围，5.09-9.37）呈正相关（P = 0.0001）。对于直径大于5 mm的痣，经染色体校正的端粒长度也与痣计数相关（P = 0.04）。痣计数最高的受试者的平均年龄调整端粒长度比最低类别的受试者长150 bp。白色细胞端粒长度与痣数量和大小之间的正相关性可能反映了端粒较长个体的复制潜力增加（衰老减少），这可能不是黑素细胞特异性的。了解影响痣的诱导和退化的机制不仅有助于了解黑色素瘤的病理生理学，而且还应该阐明衰老和癌症之间的复杂关系。
Nevus counts represent one of the strongest risk factors for melanoma. They appear in childhood and adolescence and involute from middle age onwards. Recent evidence has shown that nevus cells undergo oncogene-induced senescence involving the p16/retinoblastoma pathway. However, telomere length also influences senescence in proliferative somatic cells and varies between individuals. This study explores whether telomere length measured in white cells is associated with nevus count and size in 1,897 Caucasian women ages 18 to 79 years. Total body nevus counts were positively correlated with white cell telomere length (mean, 7.09 kbp; range, 5.09-9.37) after adjustment for age (P = 0.0001). Age-adjusted telomere length was also associated with nevus count for nevi above 5 mm in diameter (P = 0.04). Subjects in the top category for nevus count had an average age-adjusted telomere length 150 bp longer than those in the lowest category. The positive correlation between white cell telomere length and nevi number and size may reflect an increased replicative potential (reduced senescence) in individuals with longer telomeres, which may not be melanocyte specific. Understanding mechanisms influencing the induction and involution of nevi will not only help in understanding the pathophysiology of melanoma but should also shed light on the complex relationship between aging and cancer.