New insights into uteroplacental perfusion: Quantitative analysis using Doppler and contrast-enhanced ultrasound imaging
New insights into uteroplacental perfusion: Quantitative analysis using Doppler and contrast-enhanced ultrasound imaging
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DOI：
10.1016/j.placenta.2013.01.019
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发表时间：
2013-05-01
期刊：
影响因子：
3.8
通讯作者：
Perrotin, F.
中科院分区：
文献类型：
--
作者：
Arthuis, C. J.;Novell, A.;Perrotin, F.
目的：应用多普勒超声(DUS)和超声造影(CEUS)监测和量化妊娠大鼠子宫胎盘血流灌注。方法：14只大鼠随机分为CEUS组和对照组。分别于妊娠第8、11、14、17、19、20天用彩色多普勒超声检测两组子宫动脉、弓状动脉和脐动脉的阻力指数(RI)、搏动指数和血流速度。在第14天、第17天和第20天，其中一组也接受了CEU检查。结果：DUS测量显示子宫动脉和弓状动脉从第14天到第17天的RI降低(P<；0.01)，而血流速度增加(P<；0.01和P<；0.05)。超声造影定量子宫胎盘血流灌注显示子宫系膜三角(P<；0.01)和胎盘(P<；0.05)的血容量和局部血流量从第14天到第20天增加。在CEUS破坏-补充模式下，血流参数的变化趋势与团注模式相似。脐静脉和胎儿脑室内均未检测到微泡。两组仔鼠的体重没有显著差异。结论：CEUS对胎盘血流灌注的估计与DUS提供的数据相补充。(C)2013爱思唯尔有限公司。保留所有权利。
Objective: To monitor and quantify uteroplacental perfusion in rat pregnancies by Doppler ultrasound (DUS) and contrast-enhanced ultrasound (CEUS).Methods: Fourteen rats were randomized in two groups (the CEUS group and the control group). On days 8, 11, 14, 17, 19 and 20 of gestation, we used DUS to measure the resistance index (RI), pulsatility index and blood velocity in the uterine, arcuate and umbilical arteries in both groups. On days 14, 17 and 20, one group was also examined by CEUS. Quantitative perfusion parameters were calculated in 4 compartments (mesometrial triangle, placenta, umbilical cord and fetus) and compared.Results: The DUS measurement showed that the RI of the uterine and arcuate arteries decreased (p < 0.01) from day 14 to day 17, while velocity increased each of these arteries (p < 0.01 and p < 0.05, respectively). Quantification of uteroplacental perfusion by CEUS in bolus mode revealed that blood volume and local blood flow increased from day 14 to day 20 in the mesometrial triangle (p < 0.01) and the placenta (p < 0.05). In the CEUS destruction-replenishment mode, the perfusion parameters showed trends similar to those observed in bolus mode. No microbubbles were detected in the umbilical vein or fetal compartments. The weights of pups in the two groups did not differ significantly.Conclusions: CEUS estimates of placental perfusion complement the data provided by DUS. (C) 2013 Elsevier Ltd. All rights reserved.