Outbreak of SARS-CoV-2 B.1.617.2 (delta) variant in a nursing home 28 weeks after two doses of mRNA anti-COVID-19 vaccines: evidence of a waning immunity.
Outbreak of SARS-CoV-2 B.1.617.2 (delta) variant in a nursing home 28 weeks after two doses of mRNA anti-COVID-19 vaccines: evidence of a waning immunity.
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DOI：
10.1016/j.cmi.2021.12.013
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发表时间：
2022-04
期刊：
影响因子：
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通讯作者：
Saugo M
中科院分区：
文献类型：
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作者：
Pierobon A;Zotto AD;Antico A;De Antoni ME;Vianello L;Gennari M;Di Caprio A;Russo F;Brambilla G;Saugo M
描述意大利东北部一家小型养老院的居民（n = 69）和卫生工作者（n = 69）中爆发的严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）B.1.617.2（Delta）变异体疫情，完全疫苗接种覆盖率分别为91%和82%。评估针对SARS-CoV-2感染和2019年严重冠状病毒病（COVID-19）的mRNA疫苗加强剂量后28周的抗刺突IgG滴度。在48小时内从指示病例收集血清;通过商业定量测定法测定抗刺突IgG（表示为WHO结合抗体单位（BAU）/mL）;使用RT-PCR诊断SARS-CoV-2，并进行全基因组测序以进行谱系表征。根据抗刺突IgG滴度（≤50、51-1000和> 1000 BAU/mL）对居民进行分组，并测量由此产生的对感染和严重疾病的保护。在完全接种疫苗且既往无SARS-CoV-2感染的59名居民中，没有卫生工作者和14名（24%）居民显示抗刺突IgG ≤50 BAU/mL（单侧Fisher精确检验，p 0.011）。在这些居民中，抗刺突IgG水平≤50 BAU/mL导致SARS-CoV-2感染（相对风险1.55，95%CI 1.17-2.05）和严重COVID-19（相对风险5.33，95%CI 1.83-15.57）的风险较高。在第二次接种后28周，血清中SARS-CoV-2中和抗刺突IgG水平较低，与疫苗保护作用减弱平行。
To describe a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.617.2 (Delta) variant outbreak among residents (n = 69) and health workers (n = 69) of a small nursing home in northeastern Italy, with full vaccination coverage of 91% and 82%, respectively. Evaluation of the anti-Spike IgG titres 28 weeks after the mRNA vaccine booster dose against SARS-CoV-2 infection and severe coronavirus disease 2019 (COVID-19). Sera were collected within 48 hours from the index case; anti-Spike IgG was determined (expressed as WHO binding antibody units (BAU)/mL) through a commercial quantitative assay; SARS-CoV-2 was diagnosed using RT-PCR, and full-genome sequencing was performed for lineage characterization. Residents were grouped according to anti-Spike IgG titres (≤50, 51–1000 and > 1000 BAU/mL) and the resulting protection against infection and severe disease was measured. None of the health workers and 14 of the 59 (24%) residents fully vaccinated and without a previous SARS-CoV-2 infection showed anti-Spike IgG ≤50 BAU/mL (one-sided Fisher exact test, p 0.011). Among these residents, a level of anti-Spike IgG ≤50 BAU/mL resulted in a higher risk of SARS-CoV-2 infection (relative risk 1.55, 95% CI 1.17–2.05) and severe COVID-19 (relative risk 5.33, 95% CI 1.83–15.57). Low levels of SARS-CoV-2 neutralizing anti-Spike IgG in serum 28 weeks after the administration of the second dose parallel the waning of vaccine protection.
DOI：
10.15585/mmwr.mm7034e3
发表时间：
2021-08-27
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
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作者：
Nanduri S;Pilishvili T;Derado G;Soe MM;Dollard P;Wu H;Li Q;Bagchi S;Dubendris H;Link-Gelles R;Jernigan JA;Budnitz D;Bell J;Benin A;Shang N;Edwards JR;Verani JR;Schrag SJ
通讯作者：
Schrag SJ
英格兰医疗工人的COVID-19疫苗覆盖范围以及BNT162B2 mRNA疫苗对感染的有效性（Siren）：一项前瞻性，多中心，队列研究。
DOI：
10.1016/s0140-6736(21)00790-x
发表时间：
2021-05-08
期刊：
Lancet (London, England)
影响因子：
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作者：
Hall VJ;Foulkes S;Saei A;Andrews N;Oguti B;Charlett A;Wellington E;Stowe J;Gillson N;Atti A;Islam J;Karagiannis I;Munro K;Khawam J;Chand MA;Brown CS;Ramsay M;Lopez-Bernal J;Hopkins S;SIREN Study Group
通讯作者：
SIREN Study Group