Racial Differences in Estimated GFR Decline, ESRD, and Mortality in an Integrated Health System
Racial Differences in Estimated GFR Decline, ESRD, and Mortality in an Integrated Health System
复制标题
DOI：
10.1053/j.ajkd.2013.01.019
复制
发表时间：
2013-08-01
影响因子：
13.2
通讯作者：
Jacobsen, Steven J.
中科院分区：
文献类型：
--
作者：
Derose, Stephen F.;Rutkowski, Mark P.;Jacobsen, Steven J.
背景资料：目前的证据并没有明确确定肾功能下降和死亡率对终末期肾病（ESRD）发病率种族差异的贡献。我们使用观察到的估计肾小球滤过率（eGFR）来预测肾衰竭的发病时间，并检查死亡率以更好地了解这些种族差异。研究设计：回顾性队列。设置和参与者：Kaiser Permanente南加州的成年成员2003-2009年，进行了2次以上血清肌酐检测，检测间隔超过180天：526，498名白人，350，919名西班牙裔，136，923名黑人和105，476名亚洲人。预测因素：人种/种族。结局：ESRD（透析或移植）;死亡率。测量：eGFR下降采用线性回归建模。根据预测的eGFR预测肾衰竭
Background: Current evidence does not clearly identify the contribution of kidney function decline and mortality to racial disparities in end-stage renal disease (ESRD) incidence. We used observed estimated glomerular filtration rate (eGFR) to project the time of onset of kidney failure and examined mortality to better understand these racial disparities.Study Design: Retrospective cohort.Setting & Participants: Adult members of Kaiser Permanente Southern California in 2003-2009 with more than 2 serum creatinine tests and more than 180 days between tests: 526,498 whites, 350,919 Hispanics, 136,923 blacks, and 105,476 Asians.Predictor: Race/ethnicity.Outcomes: ESRD (dialysis or transplantation); mortality.Measurements: eGFR decline was modeled using linear regression. Kidney failure was projected based on predicted eGFR