A model for red blood cell motion in bifurcating microvessels
A model for red blood cell motion in bifurcating microvessels
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DOI：
10.1016/s0301-9322(99)00096-8
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发表时间：
2000-09-01
影响因子：
3.8
通讯作者：
Secomb, TW
中科院分区：
文献类型：
--
作者：
El-Kareh, AW;Secomb, TW
开发了红细胞在发散的微血管分叉中运动的理论模型，其中下游分支尺寸相等但接收不同的流量。该模型用于研究由于颗粒形状和流动不对称而引起的红细胞穿过底层流动流线的迁移。细胞与细胞相互作用的影响被忽略。流动红细胞的形状近似于刚性球帽。在均匀剪切流中，此类颗粒周期性旋转并绕流体流线振荡，没有净迁移。然而，由于颗粒缺乏前后对称性，净迁移可能发生在不均匀流中。开发了代表分叉的非均匀流场：流由两个平行板界定，并由圆柱形柱分开。发现只有上游方向分布不均匀且不对称时才会发生显着的迁移。该模型表明，如果细胞以随机方向接近分叉，则先前分叉模型中做出的假设（红细胞遵循流体流线）是合理的。 (C) 2000 Elsevier Science Ltd. 保留所有权利。
A theoretical model is developed for red blood cell motion in a diverging microvessel bifurcation, where the downstream branches are equal in size but receive different flows. The model is used to study migration of red cells across streamlines of the underlying flow, due to particle shape and flow asymmetry. Effects of cell-cell interactions are neglected. Shapes of flowing red cells are approximated by rigid spherical caps. In uniform shear flows, such particles rotate periodically and oscillate about fluid streamlines with no net migration. However, net migration can occur in non-uniform flows due to the particles' lack of fore-aft symmetry. A nonuniform flow field representative of a bifurcation is developed: flow bounded by two parallel plates, and divided by a cylindrical post. Significant migration is found to occur only with a nonuniform and asymmetric distribution of upstream orientations. The model suggests that the assumption made in previous models of bifurcations, that red cells follow fluid streamlines, is justified if cells approach the bifurcations with random orientations. (C) 2000 Elsevier Science Ltd. All rights reserved.