A pilot randomized clinical trial of two medication adherence and drug use interventions for HIV+ crack cocaine users.
A pilot randomized clinical trial of two medication adherence and drug use interventions for HIV+ crack cocaine users.
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DOI：
10.1016/j.drugalcdep.2010.12.016
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发表时间：
2011-07-01
影响因子：
4.2
通讯作者：
Marzani-Nissen, Gabrielle
中科院分区：
文献类型：
--
作者：
Ingersoll, Karen S.;Farrell-Carnahan, Leah;Cohen-Filipic, Jessye;Heckman, Carolyn J.;Ceperich, Sherry D.;Hettema, Jennifer;Marzani-Nissen, Gabrielle
快克可卡因的使用破坏了对高效抗逆转录病毒治疗（HAART）的依从性。这项试点随机临床试验测试了基于信息-动机-行为技能模型的2种干预措施的可行性和有效性，以提高HAART依从性并减少快克可卡因问题。参与者是54名使用快克可卡因和HIV的成年人，HAART依从性<90%。大多数参与者是非洲裔美国人（82%），异性恋者（59%）和快克可卡因依赖者（92%）。过去两周的平均依从性为58%。可检测到平均病毒载量（VL）（log VL 2.97）。干预措施包括6次动机访谈+反馈和技能建设（MI+），或视频信息+汇报（视频+），为期8周。主要结局是14天时间轴随访的依从性和3个月和6个月时的成瘾严重程度指数（ASI）药物综合评分。重复测量ANOVA评估干预措施的主要影响和条件的相互作用。在这两种情况下，3个月时依从性显着增加，ASI药物综合评分显着降低，并维持在6个月，代表中等效应量。未观察到组间差异。两组均未观察到VL变化。治疗的可信度、保留率和满意度都很高，并且不因病情而异。在这项试点研究中，咨询和视频干预都能持久地改善快克可卡因使用者和依从性差者的依从性和药物问题。应在坚持性差的吸毒者中进一步测试这些干预措施。视频干预对于艾滋病毒感染者和吸毒者来说可能是可行的和可扩展的。
Crack cocaine use undermines adherence to highly active antiretroviral therapy (HAART). This pilot randomized clinical trial tested the feasibility and efficacy of 2 interventions based on the Information-Motivation-Behavioral Skills model to improve HAART adherence and reduce crack cocaine problems. Participants were 54 adults with crack cocaine use and HIV with <90% HAART adherence. Most participants were African-American (82%) heterosexual (59%), and crack cocaine dependent (92%). Average adherence was 58% in the past 2 weeks. Average viral loads (VL) were detectable (log VL 2.97). The interventions included 6 sessions of Motivational Interviewing plus feedback and skills building (MI+), or Video information plus debriefing (Video+) over 8 weeks. Primary outcomes were adherence by 14-day timeline follow-back and Addiction Severity Index (ASI) Drug Composite Scores at 3 and 6 months. Repeated measures ANOVA assessed main effects of the interventions and interactions by condition. Significant increases in adherence and reductions in ASI Drug Composite Scores occurred in both conditions by 3 months and were maintained at 6 months, representing medium effect sizes. No between group differences were observed. No VL changes were observed in either group. Treatment credibility, retention, and satisfaction were high and not different by condition. A counseling and a video intervention both improved adherence and drug problems durably among people with crack cocaine use and poor adherence in this pilot study. The interventions should be tested further among drug users with poor adherence. Video interventions may be feasible and scalable for people with HIV and drug use.
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影响因子：
4.4
作者：
Amico, K. Rivet;Barta, William;Fisher, William A.
通讯作者：
Fisher, William A.
影响因子：
3.8
作者：
Cook, Judith A.;Burke-Miller, Jane K.;Cohen, Mardge H.;Cook, Robert L.;Vlahov, David;Wilson, Tracey E.;Golub, Elizabeth T.;Schwartz, Rebecca M.;Howard, Andrea A.;Ponath, Claudia;Plankey, Michael W.;Levine, Andrea;Grey, Dennis D.
通讯作者：
Grey, Dennis D.
影响因子：
3.7
作者：
Gilbert, Paul;Ciccarone, Daniel;Gansky, Stuart A.;Bangsberg, David R.;Clanon, Kathleen;McPhee, Stephen J.;Calderon, Sophia H.;Bogetz, Alyssa;Gerbert, Barbara
通讯作者：
Gerbert, Barbara
DOI：
10.1080/09540120902730013
发表时间：
2009-01-01
影响因子：
1.7
作者：
Chiasson, Mary Ann;Shaw, Francine Shuchat;Hartel, Diana
通讯作者：
Hartel, Diana
影响因子：
5.4
作者：
Bakeman, R
通讯作者：
Bakeman, R