Potentially thrombogenic materials in factor IX concentrates.
Potentially thrombogenic materials in factor IX concentrates.
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IX 因子浓缩物中可能存在血栓形成物质。
DOI：
10.1055/s-0038-1647857
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
Aronson Dl
中科院分区：
文献类型：
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作者：
Kingdon Hs;Lundblad Rl;Veltkamp Jj;Aronson Dl
一段时间以来，人们一直怀疑从人血浆中提取并用于治疗性输注的因子XI浓缩物具有潜在的血栓形成性。在目前的研究中，检测是在体外和体内进行的潜在的血栓形成物质。可以根据检测到的凝血物质的量对各种材料进行排序。对于不含肝素的浓缩物，体内和体外测定结果基本一致，相关系数为0.77。血栓性测定与抗凝血酶III含量之间无相关性。我们的结论是，许多目前可用的浓缩因子IX含有大量潜在的血栓形成酶，这一事实必须考虑在决定是否使用它们治疗。
Factor XI concentrates manufactured from human plasma and intended for therapeutic infsuion in man have been suspected for some time of being potentially thrombogenic. In the current studies, assays were carried out in vitro and in vivo for potentially thrombognic materials. It was possible to rank the various materials tested according to the amount of thromboninic material detected. For concentrates not containing heparin, there was substantial agreement between the in vivo and in vitro assays, with a coefficient of correlation of 0.77. There was no correlation between the assays for thrombogenicity and the antithrombin III content. We conclude that many presently availabel concentrates of Factor IX contain substantial amounts of potentially thrombogenic enzymes, and that this fact must be considered in arriving at the decision whether or not to use them therapeutically.