The E1 initiator recognizes multiple overlapping sites in the papillomavirus origin of DNA replication
The E1 initiator recognizes multiple overlapping sites in the papillomavirus origin of DNA replication
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DOI：
10.1128/jvi.75.1.292-302.2001
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发表时间：
2001-01-01
影响因子：
5.4
通讯作者：
Stenlund, A
中科院分区：
文献类型：
--
作者：
Chen, G;Stenlund, A
A common feature of replicator sequences from a variety of organisms is multiple binding sites for an initiator protein. By binding to the replicator, initiators mark the site and contribute to melting or distortion of the DNA. We have defined the recognition sequence for the papillomavirus El initiator and determined the arrangement of binding sites in the viral origin of replication. We show that El recognizes a hexanucleotide sequence which is present in overlapping arrays in virtually all papillomavirus replicators. Binding of the initiator to these sites would result in the formation of a closely packed array of El molecules that wrap around the double helix.
