Association between liver fibrosis and insulin sensitivity in chronic hepatitis c patients
Association between liver fibrosis and insulin sensitivity in chronic hepatitis c patients
复制标题
DOI：
10.1111/j.1572-0241.2006.00835.x
复制
发表时间：
2006-12-01
影响因子：
9.8
通讯作者：
Eguchi, Katsumi
中科院分区：
文献类型：
--
作者：
Taura, Naota;Ichikawa, Tatsuki;Eguchi, Katsumi
背景：多项临床研究表明，丙型肝炎病毒（HCV）引起的慢性肝炎与糖尿病的发生之间可能存在联系。我们通过测量胰岛素敏感性和 β 细胞功能，研究了 HCV 感染患者的肝纤维化和葡萄糖耐受不良之间的关联。方法：本研究共招募了 83 名慢性 HCV 感染患者。我们评估了所有患者在空腹状态下的胰岛素敏感性和 β 细胞功能（胰岛素抵抗稳态模型评估 [HOMA-R] 和 β 细胞功能稳态模型评估 [HOMA-β]）和口服 75 g 葡萄糖后（全身胰岛素敏感性指数 [WBISI] 和 Delta-胰岛素/Delta-葡萄糖 30）。 结果：在多变量分析中，严重纤维化是与胰岛素相关的唯一独立因素阻力。轻度纤维化患者 (N = 34) 和重度纤维化患者 (N = 49) 的 HOMA-R (P = 0.0063) 和 WBISI (P = 0.0159) 均存在显着差异。尽管与轻度纤维化受试者相比，重度纤维化受试者的 HOMA-β 显着升高（P= 0.0169），但 Delta-胰岛素/Delta-葡萄糖 30 在肝纤维化阶段没有显着差异，表明肝纤维化与 β 细胞功能之间存在不确定的关联。 结论：我们的研究结果表明，HCV 感染患者肝纤维化的发生与胰岛素抵抗相关。
BACKGROUND: Several clinical studies have suggested a possible link between chronic hepatitis caused by hepatitis C virus (HCV) and the development of diabetes mellitus. We investigated the association between liver fibrosis and glucose intolerance in HCV-infected patients by measuring insulin sensitivity and beta-cell function.METHOD: A total of 83 chronic HCV-infected patients were recruited into this study. We evaluated insulin sensitivity and beta-cell function of all patients in a fasting state (homeostasis model assessment of insulin resistance [HOMA-R] and homeostasis model assessment of beta-cell function [HOMA-beta]) and after an oral load of 75 g glucose (whole-body insulin sensitivity index [WBISI] and Delta-insulin/Delta-glucose 30).RESULTS: In a multivariate analysis, severe fibrosis was the only independent factor associated with insulin resistance. There were significant differences in both HOMA-R (P = 0.0063) and WBISI (P = 0.0159) between patients with mild fibrosis (N = 34) and those with severe fibrosis (N = 49). Although HOMA-beta was increased significantly in the subjects with severe fibrosis compared with those with mild fibrosis (P= 0.0169), Delta-insulin/Delta-glucose 30 showed no significant difference in stage of liver fibrosis, suggesting an uncertain association between liver fibrosis and beta-cell function.CONCLUSION: Our findings suggest that the development of liver fibrosis is associated with insulin resistance in HCV-infected patients.