Expected linkage disequilibrium for a neutral locus linked to a chromosomal arrangement.
Expected linkage disequilibrium for a neutral locus linked to a chromosomal arrangement.
复制标题
与染色体排列相关的中性位点的预期连锁不平衡。
作者：
C. Strobeck
对于与染色体排列相关的中性基因座，通过强平衡选择保持在群体中，得出了平方连锁不平衡的期望值。对于给定的重组值，期望的平方连锁不平衡随着维持排列的选择强度的增加而减小。给出了期望的方形连杆机构不平衡的暂态行为。这一理论适用于与果蝇物种的倒位密切相关的基因座，以及与月见草环形目物种的易位复合体的差异片段紧密连锁的基因座。在这两种情况下，在自然种群中观察到的强连锁不平衡都可以用随机漂移来解释。
The expected value of the squared linkage disequilibrium is derived for a neutral locus associated with a chromosomal arrangement that is maintained in the population by strong balancing selection. For a given value of recombination, the expected squared linkage disequilibrium is shown to decrease as the intensity of selection maintaining the arrangement increases. The transient behavior of the expected square linkage disequilibrium is also derived. This theory applies to loci that are closely linked to inversions in Drosophila species and to loci closely linked to the differential segments of the translocation complexes in ring-forming species of Oenothera. In both cases the strong linkage disequilibria that have been observed in natural populations can be explained by random drift.