The functionally diverse roles of tribbles
The functionally diverse roles of tribbles
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DOI：
10.1042/bst20130105
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发表时间：
2013-08-01
影响因子：
3.9
通讯作者：
Keeshan, Karen
中科院分区：
文献类型：
--
作者：
Lohan, Fiona;Keeshan, Karen
Tribbles是蛋白质的假激酶家族的成员，迄今为止没有检测到相关的激酶活性。由于tribbles似乎不起激酶的作用，因此围绕其功能分类存在争议。已经提出Tribbles作为接头分子，促进其靶蛋白的降解。还提出了Tribbles介导MAPK（促分裂原活化蛋白激酶）级联的信号变化，并且还起到干扰已知激酶活性的诱饵激酶的作用。本文综述了tribbles作为介导降解的分子衔接子的功能不同的作用，信号级联的变化和作为诱饵激酶的作用。
Tribbles are members of the pseudokinase family of proteins, with no associated kinase activity detectable to date. As tribbles appear not to function as kinases, there has been debate surrounding their functional classification. Tribbles have been proposed to function as adaptor molecules facilitating degradation of their target proteins. Tribbles have also been proposed to mediate signalling changes to MAPK (mitogen-activated protein kinase) cascades and also to function as decoy kinases interfering with the activity of known kinases. The present review discusses the functionally divergent roles of tribbles as molecular adaptors mediating degradation, changes to signalling cascades and action as decoy kinases.