Unsuccessful diagnostic cytogenetic analysis is a poor prognostic feature in acute myeloid leukaemia.
Unsuccessful diagnostic cytogenetic analysis is a poor prognostic feature in acute myeloid leukaemia.
复制标题
不成功的诊断性细胞遗传学分析是急性髓系白血病的一个不良预后特征。
DOI：
10.1111/bjh.12625
复制
发表时间：
2014-01
影响因子：
6.5
通讯作者：
Appelbaum FR
中科院分区：
文献类型：
--
作者：
Medeiros BC;Othus M;Estey EH;Fang M;Appelbaum FR
染色体显带分析是鉴别急性髓性白血病（AML）复发性细胞遗传学异常的金标准方法。它允许将AML患者分层为对治疗和生存具有不同反应的亚组。不幸的是，在约10%的病例中，各种问题阻碍了细胞遗传学评价（不成功的细胞遗传学[UC]），并且对这些患者的结局知之甚少。为了更好地确定AML患者细胞遗传学不成功的意义，我们比较了94例（6%）患者的基线特征和预后影响，这些患者的标准中期分析结果不可接受，其余1403例AML患者成功进行细胞遗传学分析，接受连续SWOG方案治疗。UC的发病率随着年龄的增长而增加，60岁以上患者的发病率最高。这些患者对诱导化疗的反应率较低（完全缓解率为43%），5年生存率低（16%），尤其是60岁以上的患者（<5%）。完全缓解率和生存率与不良核型患者相似。早期死亡率没有增加。这些结果表明，UC随着年龄的增长而增加，并预测不良结局，类似于不良核型患者的结局。
Chromosome banding analysis is the gold standard method for the identification of recurrent cytogenetic abnormalities in acute myeloid leukaemia (AML). It allows stratification of AML patients into subgroups with distinct responses to therapy and survival. Unfortunately a variety of issues hamper cytogenetic evaluation in ~10% of cases (unsuccessful cytogenetics [UC]) and the outcome of these patients is poorly understood. To better define the significance of unsuccessful cytogenetic in patients with AML, we compared the baseline characteristics and the prognostic impact of the 94 (6%) patients, whose standard metaphase analysis yielded unacceptable results, to the remaining 1403 AML patients with successful cytogenetic analysis treated on successive SWOG protocols. The incidence of UC increased with age, with peak incidence in patients older than 60 years. These patients had a lower response rate to induction chemotherapy (complete remission rate of 43%) and dismal 5-year survival rates (16%), which was especially poor in patients older than 60 years (<5%). The complete remission and survival rates were similar to those seen in patients with unfavorable karyotype. The early death rate was not increased. These results suggest that UC increases with age and predict for poor outcomes, similar to the outcomes of patients with unfavorable karyotype.
登录
查看更多内容
影响因子：
20.3
作者：
Fischer, K;Scholl, C;Dohner, H
通讯作者：
Dohner, H
影响因子：
1.9
作者：
Dougherty, Margaret J.;Wilmoth, Donna M.;Biegel, Jaclyn A.
通讯作者：
Biegel, Jaclyn A.
影响因子：
158.5
作者：
Lowenberg, Bob;Pabst, Thomas;Ossenkoppele, Gert J.
通讯作者：
Ossenkoppele, Gert J.
影响因子：
20.3
作者：
List, AF;Kopecky, KJ;Appelbaum, FR
通讯作者：
Appelbaum, FR
影响因子：
20.3
作者：
Medeiros, Bruno C.;Othus, Megan;Appelbaum, Frederick R.
通讯作者：
Appelbaum, Frederick R.