Genetic variation rs10484761 on 6p21.1 derived from a genome-wide association study is associated with gastric cancer survival in a Chinese population
Genetic variation rs10484761 on 6p21.1 derived from a genome-wide association study is associated with gastric cancer survival in a Chinese population
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来自全基因组关联研究的 6p21.1 上的遗传变异 rs10484761 与中国人群的胃癌生存相关
DOI：
10.1016/j.gene.2013.11.087
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发表时间：
2014-02-15
期刊：
影响因子：
3.5
通讯作者：
Zhang, Zhengdong
中科院分区：
文献类型：
--
作者：
Kang, Meiyun;Ding, Ojie;Zhang, Zhengdong
在中国人食管鳞癌全基因组关联研究（GWAS）中发现了一个新的单核苷酸多态性（SNP）rs 10484761。我们假设SNP rs 10484761 TIC与胃癌生存相关。我们对940例手术切除的胃癌患者进行SNP rs 10484761基因分型。使用Kaplan-Meier生存分析、对数秩检验和考克斯比例风险模型来评估SNP rs 10484761与胃癌生存之间的相关性。在显性模型中，携带TC/CC基因型者的生存时间显著缩短（log-rank P = 0.005），尤其是在老年男性患者、贲门肠道肿瘤（贲门癌HR = 3.41，95%CI = 1.08-1.84，膀胱型HR = 1.64，95%CI-= 1.14-2.37），肿瘤大小5 cm（HR = 1.41，95%CI = 0.56-0.99），TI深度浸润（HR = 234，95%CI = 1.20-4.56），淋巴结转移（HR = 1.51，95%CI = 1.19-1.96），无远处转移（HR =-133，95% CI = 1.05-1.68）、TNM分期III + IV期（HR = 150，95% CI = 1.13-1.98）和化疗（HR = 1.53，95% CI = 1.17-1.99）。结果表明，SNP rs 10484761与胃癌的预后相关，提示该基因变异可能作为中国人群胃癌生存预测的一个潜在标记。(C)2013爱思唯尔有限公司版权所有。
A recent genome-wide association study (GWAS) on esophageal squamous-cell carcinoma (ESCC) among Chinese people has discovered a novel single nucleotide polymorphism (SNP) rs10484761 on 6p21.1 region. We hypothesized that SNP rs10484761 TIC is associated with survival of gastric cancer. We genotyped SNP rsl 0484761 in 940 gastric cancer patients treated with surgical resection. Kaplan-Meier survival analysis, log-rank test, and Cox proportional hazard models were used to evaluate the association between the SNP rs10484761 and gastric cancer survival. In the dominant model, those who carry TC/CC genotypes had a significant shorter survival time (log-rank P = 0.005), especially in the subgroups of aged male patients, cardia intestinal tumor (HR = 3.41,95% CI = 1.08-1.84 for cardia cancer and HR = 1.64, 95% CI -= 1.14-2.37 for intestinal-type), tumor size 5 cm (HR = 1.41,95% CI = 0.56-0.99), TI depth invasion (HR = 234,95% CI = 1.20-4.56), lymph node metastasis (HR = 1.51, 95% CI = 1.19-1.96), no distant metastasis (HR =- 133,95% CI = 1.05-1.68), TNM stage III + IV (HR = 150,95% CI = 1.13-1.98), and with chemotherapy (HR = 1.53, 95% CI = 1.17-1.99). The results indicated that SNP rs10484761 was associated with prognosis of gastric cancer, suggesting that this genetic variant may serve as a potential marker to predict the survival of gastric cancer in Chinese population. (C) 2013 Elsevier B.V. All rights reserved.