Bioionic Liquids: Enabling a Paradigm Shift Toward Advanced and Smart Biomedical Applications
Bioionic Liquids: Enabling a Paradigm Shift Toward Advanced and Smart Biomedical Applications
复制标题
DOI：
10.1002/aisy.202200306
复制
发表时间：
2023-02
影响因子：
7.4
通讯作者：
Baishali Kanjilal;Yangzhi Zhu;Vaishali Krishnadoss;Janitha M. Unagolla;Parnian Saemian;Alessia Caci;Danial Cheraghali;Iman Dehzangi;A. Khademhosseini;Iman Noshadi
中科院分区：
文献类型：
--
作者：
Baishali Kanjilal;Yangzhi Zhu;Vaishali Krishnadoss;Janitha M. Unagolla;Parnian Saemian;Alessia Caci;Danial Cheraghali;Iman Dehzangi;A. Khademhosseini;Iman Noshadi
离子液体具有良好的离子导电性、电化学稳定性、热稳定性和不燃性等特性，在生物医学领域具有广阔的应用前景。它们的细胞相容性的限制通过使用衍生自生物分子如胺、糖和有机酸的生物离子液体（BILs）而增强。BIL可以使用可定制的化学方法合成，使其能够固定在生物聚合物上。例如，胆碱离子及其衍生物已在组织工程和药物递送系统中发现了显著的兴趣。离子掺杂的BIL官能化聚合物及其复合材料也可用于设计pH和电响应致动器和传感器。BIL官能化聚合物的细胞相容性和低免疫原性使其能够用于储能装置以及可植入装置。这些装置在核酸递送和分子医学中获得认可和重要性。本文综述了BILs在生物医学应用中的最新进展。具体而言，审查探讨BILs作为生物聚合物功能化的代理商，并强调BILs作为超分子离子网络的溶剂。
Ionic liquids (ILs) exhibit unique properties of good ionic conductivity, electrochemical and thermal stability, and nonflammability, which make them promising candidates for biomedical applications. The limitations of their cytocompatibility are enhanced by using bioionic liquids (BILs) derived from biological molecules such as amines, sugars, and organic acids. BILs can be synthesized using tailorable chemistries that enable their immobilization onto biopolymers. For example, the cholinium ion and its derivatives have found significant interest in tissue engineering and drug delivery systems. Ion‐doped BIL‐functionalized polymers and their composites can also be used to design pH and electrical responsive actuators and sensors. The cytocompatibility and low immunogenicity of BIL‐functionalized polymers enable the possibilities of their use for power storage devices as well as implantable devices. These devices are gaining recognition and importance in nucleic acid delivery and molecular medicine. This review focuses on the recent advances of BILs in biomedical applications. Specifically, the review explores BILs as agents for biopolymer functionalization and highlights BILs as solvents for supermolecular ionic networks.