Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp.
Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp.
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DOI：
10.3201/eid1402.070677
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发表时间：
2008-02
影响因子：
11.8
通讯作者：
Nordmann, Patrice
中科院分区：
文献类型：
--
作者：
Cattoir, Vincent;Poirel, Laurent;Aubert, Camille;Soussy, Claude-James;Nordmann, Patrice
质粒介导的qnr基因在肠杆菌科外的鉴定强调了这些耐药决定因素可能在革兰氏阴性棒内扩散。我们在塞纳河（法国巴黎）不同地点收集的几个水样中寻找质粒介导的喹诺酮类药物耐药决定因素。从点状气单胞菌亚种中鉴定出qnrS2基因。A.媒体；qnrS2基因位于两个分离株的incu型质粒上，导致喹诺酮类药物和氟喹诺酮类药物一旦转移到大肠杆菌中，其MIC值升高。发现的qnrS2基因是一个新的遗传结构的一部分，与一个移动插入盒元件相对应。质粒介导的qnr基因在肠杆菌科外的鉴定强调了这些耐药决定因素可能在革兰氏阴性棒内扩散。
Identification of plasmid-mediated qnr genes outside Enterobacteriaceae underlines a possible diffusion of those resistance determinants within gram-negative rods. We searched for plasmid-mediated quinolone resistance determinants of the Qnr type in several water samples collected at diverse locations from the Seine River (Paris, France). The qnrS2 genes were identified from Aeromonas punctata subsp. punctata and A. media. The qnrS2 gene was located on IncU-type plasmids in both isolates, which resulted in increased MIC values of quinolones and fluoroquinolones, once they were transferred into Escherichia coli. The qnrS2 gene identified in A. punctata was part of novel genetic structure corresponding to a mobile insertion cassette element. This identification of plasmid-mediated qnr genes outside Enterobacteriaceae underlines a possible diffusion of those resistance determinants within gram-negative rods.
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影响因子：
64.8
作者：
Beaber, JW;Hochhut, B;Waldor, MK
通讯作者：
Waldor, MK
影响因子：
4.9
作者：
Boenemann, Gabriele;Stiens, Michael;Schlueter, Andreas
通讯作者：
Schlueter, Andreas
影响因子：
2.6
作者：
KIESER, T
通讯作者：
KIESER, T
影响因子：
4.9
作者：
Jacoby, GA;Walsh, KE;Hooper, DC
通讯作者：
Hooper, DC
影响因子：
5.2
作者：
Cattoir, Vincent;Poirel, Laurent;Nordmann, Patrice
通讯作者：
Nordmann, Patrice