Dynamics of postural control in Parkinson patients with and without symptoms of freezing of gait.
Dynamics of postural control in Parkinson patients with and without symptoms of freezing of gait.
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DOI：
10.1016/j.gaitpost.2014.09.021
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发表时间：
2015-09
期刊：
影响因子：
2.4
通讯作者：
O. Pelykh;A. Klein;K. Bötzel;Z. Kosutzka;J. Ilmberger
中科院分区：
文献类型：
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作者：
O. Pelykh;A. Klein;K. Bötzel;Z. Kosutzka;J. Ilmberger
BackgroundIt已被建议，动态措施，如样本熵可能比传统的措施时，分析时间序列数据，如姿势摇摆更合适。我们评估了传统的和动态的措施，姿势摇摆帕金森病（PD）患者和不冻结epission.MethodsCOP（中心的压力）的数据记录在安静的站立，睁开眼睛，闭上眼睛，同时执行双重任务。分析了16例步态冻结患者、17例无冻结史患者和24例健康受试者的数据。使用常规措施的姿势摇摆量进行量化，而COP数据的时间结构的表征的归一化摇摆路径和样本entropy calculated.ResultsMean半径较高，样本熵较低的患者冻结症状相比，健康受试者在所有三种条件。双任务显着增加摇摆路径长度的患者冻结，而正常化的摇摆路径没有改变条件在this group.ConclusionsOur研究结果表明，姿势摇摆的特点是组合的大半径，短的正常化摇摆路径和高的COP的规则性，只有在患者冻结。这种模式在双任务范式中最为突出。这可能解释了在双重任务情况下步态冻结的发生率较高，随后福尔斯的风险较高。结果表明，动态措施可能会增加有价值的信息，在PD患者的姿势稳定性的特点。
BackgroundIt has been suggested that dynamical measures such as sample entropy may be more appropriate than conventional measures when analyzing time series data such as postural sway. We evaluated conventional and dynamical measures of postural sway in Parkinson disease (PD) patients with and without freezing episodes.MethodsCOP (center of pressure) data were recorded during quiet standing with eyes open, eyes closed and while performing a dual task. Data for 16 patients with freezing of gait, 17 patients with no history of freezing and 24 healthy subjects were analyzed. The amount of postural sway was quantified using conventional measures, whereas for the characterization of the temporal structure of the COP data the normalized sway path and sample entropy was calculated.ResultsMean radius was higher and sample entropy was lower in patients with freezing symptoms as compared to healthy subjects in all three conditions. Dual-tasking significantly increased sway path length in patients with freezing, while normalized sway path did not change over conditions in this group.ConclusionsOur findings show that postural sway is characterized by a combination of large radius, short normalized sway path and high regularity of the COP only in patients with freezing. This pattern becomes most prominent in a dual-task paradigm. This may explain higher occurrence of gait freezing in dual task situations with subsequent higher risk of falls. Results suggested that dynamic measures may add valuable information for characterizing postural stability in PD patients.