Early-life conditions and age at first pregnancy in British women
Early-life conditions and age at first pregnancy in British women
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DOI：
10.1098/rspb.2010.1726
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发表时间：
2011-06-07
影响因子：
4.7
通讯作者：
Dickins, Thomas E.
中科院分区：
文献类型：
--
作者：
Nettle, Daniel;Coall, David A.;Dickins, Thomas E.
越来越多的证据表明，雌性哺乳动物的生殖时间表可能会受到早期发育过程中所经历的条件的影响，父母投资少导致后代的生活史策略加速。在人类中，早期生活条件和青春期时间之间的关系得到了很好的研究，但对生殖行为的关注要少得多。在这里，我们在一个大型纵向研究的英国女性队列（n = 4553）中调查了早期生活状况与首次怀孕年龄（AFP）之间的关联。出生体重低于胎龄、母乳喂养时间短、童年时与母亲分离、家庭频繁搬家和缺乏父亲参与都与首次妊娠早独立相关。除了出生体重的影响，家庭社会经济地位（SEP）和队列成员的母亲的年龄在她出生的调整是强大的。儿童SEP和AFP之间的关联部分是由早期生活条件介导的，早期生活条件和AFP之间的关联部分是由儿童时期的情绪和行为问题介导的。早期生活的逆境和AFP之间的整体关系似乎是近似相加。
There is growing evidence that the reproductive schedules of female mammals can be affected by conditions experienced during early development, with low parental investment leading to accelerated life-history strategies in the offspring. In humans, the relationships between early-life conditions and timing of puberty are well studied, but much less attention has been paid to reproductive behaviour. Here, we investigate associations between early-life conditions and age at first pregnancy (AFP) in a large, longitudinally studied cohort of British women (n = 4553). Low birthweight for gestational age, short duration of breastfeeding, separation from mother in childhood, frequent family residential moves and lack of paternal involvement are all independently associated with earlier first pregnancy. Apart from that of birthweight, the effects are robust to adjustment for family socioeconomic position (SEP) and the cohort member's mother's age at her birth. The association between childhood SEP and AFP is partially mediated by early-life conditions, and the association between early-life conditions and AFP is partially mediated by emotional and behavioural problems in childhood. The overall relationship between early-life adversities and AFP appears to be approximately additive.