Increased mast cells in endocervical smears of women with dysmenorrhea
Increased mast cells in endocervical smears of women with dysmenorrhea
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DOI：
10.4103/cytojournal.cytojournal_54_17
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发表时间：
2018-11
期刊：
影响因子：
1.9
通讯作者：
S. Tsuji;K. Tsuji;H. Otsuka;T. Murakami
中科院分区：
文献类型：
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作者：
S. Tsuji;K. Tsuji;H. Otsuka;T. Murakami
背景：肥大细胞在引起痛经的腹膜子宫内膜异位症中可见。但有关宫颈肥大细胞与痛经关系的研究尚未见报道。这项研究的目的是通过宫颈涂片来评估两者之间的关系。材料和方法：选择2016-01/2016-06痛经患者填写痛经问卷，分为痛经组和对照组(无痛经组)。2例患者行宫颈刷检，并取宫颈涂片。涂片用亚甲蓝染色检测肥大细胞。显微镜下计数并记录每片的肥大细胞数。结果：89例患者进入本研究，其中痛经组34例，对照组55例。痛经组和对照组宫颈切片中肥大细胞的中位数分别为35个(四分位数范围17-58)和2个(四分位数范围0-6)。肥大细胞的数量在两组间有显著差异(P<；0.0001)。结论：痛经妇女宫颈涂片中肥大细胞明显多于无痛经妇女。
Background: Mast cells are observed in peritoneal endometriosis which causes dysmenorrhea. However, there is no report about the relationship between endocervical mast cells and dysmenorrhea. The aim of this study is to evaluate the relationship using endocervical smears. Materials and Methods: Between January 2016 and June 2016, patients filled out a questionnaire regarding dysmenorrhea and were classified into the dysmenorrhea or the control group (without dysmenorrhea). Patients underwent endocervical brushing and endocervical smears were obtained. The smears were stained with methylene blue to detect mast cells. The number of mast cells per slide was counted by microscopy and recorded. Results: Eighty-nine patients were enrolled in this study (dysmenorrhea group, 34; control group, 55). The median number of mast cells present in the endocervical one slides was 35 (interquartile range, 17–58) and 2 (interquartile range, 0–6) in the dysmenorrhea and control groups, respectively. There was a significant difference in the number of mast cells between the two groups (P < 0.0001). Conclusion: More mast cells were observed in the endocervical smears of women with dysmenorrhea than in those of women without dysmenorrhea.