Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barre syndrome
Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barre syndrome
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DOI：
10.1016/s0165-5728(02)00209-6
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发表时间：
2002-09-01
影响因子：
3.3
通讯作者：
van Doorn, PA
中科院分区：
文献类型：
--
作者：
Ang, CW;Tio-Gillen, AP;van Doorn, PA
据报道，抗半乳糖苷（GalC）抗体存在于GBS患者先前肺炎支原体（MP）感染。我们研究了抗GalC反应性的存在下，在一个大组的GBS患者的血清中使用ELISA，并与健康对照组和个人与一个简单的MP感染进行比较。12%的GBS患者存在抗GalC抗体反应性。此外，抗GalC抗体与NIP感染相关，这是一种相对温和的疾病形式和脱髓鞘特征。抗GalC抗体与NIP抗原交叉反应。总之，GBS患者中的抗GalC抗体可通过MP的分子模拟来诱导。(C)2002 Elsevier Science B.V.保留所有权利。
Anti-galactocerebroside (GalC) antibodies are reported to be present in GBS patients with preceding Mycoplasma pneumoniae (MP) infection. We investigated the presence of anti-GalC reactivity in serum of a large group of GBS patients using ELISA and compared this with healthy controls and individuals with an uncomplicated MP infection. Anti-GalC antibody reactivity was present in 12% of the GBS patients. Furthermore, anti-GalC antibodies were associated with NIP infections, a relatively mild form of the disease and demyelinating features. Anti-GalC antibodies cross-reacted with NIP antigen. In conclusion, anti-GalC antibodies in GBS patients may be induced by molecular mimicry with MP. (C) 2002 Elsevier Science B.V. All rights reserved.