The Cell Cycle Inhibitor p27 as a Prognostic Marker in Human Tumors and a Novel Target for Therapeutic Intervention

The Cell Cycle Inhibitor p27 as a Prognostic Marker in Human Tumors and a Novel Target for Therapeutic Intervention
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细胞周期抑制剂 p27 作为人类肿瘤的预后标志物和治疗干预的新靶点

DOI:
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发表时间:
2000
期刊:
影响因子:
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通讯作者:
K. Ravid
K. Ravid
中科院分区:
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文献类型:
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作者:
M. Pagano;K. Ravid

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真核细胞的细胞周期传统上分为两个主要阶段:间期和有丝分裂(M期)。间期由三个亚期组成:G1、S和G2。在M期,复制的染色体分离,细胞经历胞质分裂,产生两个子细胞。G1期的细胞内组分在使细胞准备复制其基因组(S期)中具有活性,而G2期的细胞的那些组分使细胞准备进入M期。
The cell cycle in eukaryotic cells has traditionally been divided into two major phases: interphase and mitosis (M phase). Interphase is composed of three subphases: G1, S, and G2. During M phase, the duplicated chromosomes segregate and the cell undergoes cytokinesis, giving rise to two daughter cells. Intracellular components during Gl phase are active in preparing the cells to replicate their genome (during S phase), whereas those of cells in G2 phase prepare the cells for entry into M.
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两种原发性人类肿瘤中假定癌基因 PRAD1/细胞周期蛋白 D1 过表达转录本的编码序列。
DOI: --
发表时间: 1993
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