Immune-induced flavor aversion in mice:: Modification by neonatal capsaicin treatment
Immune-induced flavor aversion in mice:: Modification by neonatal capsaicin treatment
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DOI：
10.1159/000049011
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发表时间：
2001-01-01
影响因子：
2.4
通讯作者：
Palermo-Neto, J
中科院分区：
文献类型：
--
作者：
Basso, AS;de Sá-Rocha, LC;Palermo-Neto, J
目的：探讨c-敏感纤维在免疫诱导的小鼠味觉厌恶形成中的作用。研究方法：为了破坏c-敏感性纤维，用辣椒素对小鼠进行阴道处理;在这样的处理之后，成年动物，用卵清蛋白免疫或不免疫，进行两瓶偏好测试，在水和加糖的鸡蛋白色溶液之间进行选择。结果新生儿辣椒素治疗未能成功阻止免疫诱导的对含有抗原的甜味溶液的厌恶。尽管如此，在免疫的小鼠中，那些先前用辣椒素处理过的小鼠显示出对加糖的鸡蛋白色溶液的偏好显著增加。此外，我们的数据表明，新生儿辣椒素治疗不干扰IgG 1或IgE的生产。结论：目前的结果表明，c-敏感纤维在传递由这种免疫反应产生的信号到中枢神经系统中发挥作用，从而有助于小鼠的味道厌恶的发展。版权所有（C）2001 S. Karger AG，巴塞尔。
Objective: This study was designed to evaluate the role of c-sensitive fibers in the establishment of immune-induced flavor aversion in mice. Methods: Mice were treated neonatally with capsaicin in order to destroy c-sensitive fibers; after such treatment, adult animals, immunized or not with ovalbumin, were submitted to a two-bottle preference test, with a choice between water and a sweetened egg white solution. Results. Neonatal capsaicin treatment was unsuccessful in preventing the development of immune-induced aversion to the sweetened solution containing the antigen. Nonetheless, amongst immunized mice, those which had been previously treated with capsaicin showed a significant increment in the preference for the sweetened egg white solution. Furthermore, our data showed that neonatal capsaicin treatment did not interfere with either IgG1 or IgE production. Conclusion: The present results suggest that c-sensitive fibers have a role in the transmission of the signals generated by this immune response to the central nervous system, thus contributing to the development of a flavor aversion in mice. Copyright (C) 2001 S. Karger AG, Basel.