Microbiome and intestinal ischemia/reperfusion injury.
Microbiome and intestinal ischemia/reperfusion injury.
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DOI：
10.3164/jcbn.17-137
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发表时间：
2018-07
影响因子：
2.4
通讯作者：
Fujiwara Y
中科院分区：
文献类型：
--
作者：
Nadatani Y;Watanabe T;Shimada S;Otani K;Tanigawa T;Fujiwara Y
肠缺血/再灌注损伤是一种与高死亡率相关的严重疾病。引起缺血/再灌注损伤的机制复杂，损伤形成过程涉及多种因素；然而，唯一可用的治疗方法是手术干预。近年来的研究表明，肠道微生物群在肠道缺血/再灌注损伤中发挥着关键作用，肠道缺血/再灌注损伤的形成过程中有许多因素与肠道细菌相关。据报道，在 Toll 样受体 (TLR) 中，TLR2、TLR4 及其接头蛋白、骨髓分化初级反应 88 (MyD88) 与肠缺血/再灌注损伤有关。在肠道缺血/再灌注损伤的形成过程中，氧化应激和一氧化氮也与肠道细菌有关。本综述重点关注我们目前对微生物组影响的理解，包括 TLR、氧化应激和一氧化氮对肠道缺血/再灌注损伤的作用。
Intestinal ischemia/reperfusion injury is a severe disease associated with a high mortality. The mechanisms that cause ischemia/reperfusion injury are complex and many factors are involved in the injury formation process; however, the only available treatment is surgical intervention. Recent studies demonstrated that the intestinal microbiome plays a key role in intestinal ischemia/reperfusion injury and there are many factors associated with intestinal bacteria during the formation of the intestinal ischemia/reperfusion injury. Among the Toll-like receptors (TLR), TLR2, TLR4, and their adaptor protein, myeloid differentiation primary-response 88 (MyD88), have been reported to be involved in intestinal ischemia/reperfusion injury. Oxidative stress and nitric oxide are also associated with intestinal bacteria during the formation of the intestinal ischemia/reperfusion injury. This review focuses on our current understanding of the impact of the microbiome, including the roles of the TLRs, oxidative stress, and nitric oxide, on intestinal ischemia/reperfusion injury.