Nationwide epidemiologic survey of idiopathic osteonecrosis of the femoral head.
Nationwide epidemiologic survey of idiopathic osteonecrosis of the femoral head.
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DOI：
10.1007/s11999-010-1292-x
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发表时间：
2010-10
影响因子：
4.2
通讯作者：
Hirota, Yoshio
中科院分区：
文献类型：
--
作者：
Fukushima, Wakaba;Fujioka, Mikihiro;Kubo, Toshikazu;Tamakoshi, Akiko;Nagai, Masaki;Hirota, Yoshio
尽管许多研究描述了特定研究人群中特发性股骨头坏死（ONFH）的临床特征，但这些尚未在全国范围内的研究中得到证实。因此，我们决定：（1）每年求诊的病人数目及新诊断的病人数目;及（2）病人的年龄及性别分布、潜在致病因素、疾病的严重程度及所施行的手术。我们在2005年进行了一次全国性的流行病学调查。该调查包括所有骨科在日本的分层随机抽样，根据床位数。2004年期间因特发性ONFH寻求医疗护理的患者人数估计为11，400（95%置信区间，10，100 - 12，800）。我们从其中1502例患者中获得了临床信息。年龄分布的高峰出现在40多岁。潜在的致病因素是全身性类固醇用药（51%）和习惯性饮酒（31%）。髋关节置换术是最常进行的手术（65%）。在有全身性类固醇用药史的患者中，系统性红斑狼疮最常报告（31%）为基础疾病。在40岁以下的患者中，类固醇使用是最突出的潜在致病因素（60%），髋关节置换术频繁（45%）。在65岁或65岁以上的患者中观察到更大比例的患者没有类固醇或酒精使用史（41%）。除了日本特发性ONFH的疾病负担外，我们的研究结果证实了制定预防和治疗策略的重要性，特别是在年轻人群中。IV级，预后研究。有关证据等级的完整描述，请参见作者指南。
Although numerous studies describe the clinical characteristics of idiopathic osteonecrosis of the femoral head (ONFH) in specific study populations, these have not been confirmed in countrywide studies. We therefore determined: (1) the annual number of patients seeking medical care and number of patients newly diagnosed; and (2) the distribution of the age and gender of the patients, potential causative factors, severity of the disease, and operative procedures performed. We conducted a nationwide epidemiologic survey in 2005. The survey included all orthopaedic departments in Japan by stratified random sampling according to the number of beds. The number of patients who sought medical care for idiopathic ONFH during 2004 was estimated to be 11,400 (95% confidence interval, 10,100–12,800). We obtained clinical information from 1502 of these patients. The peak in age distribution occurred in the 40s. Potential causative factors were systemic steroid administration (51%) and habitual alcohol use (31%). Hip replacement was the most frequently performed procedure (65%). Among patients with a history of systemic steroid administration, systemic lupus erythematosus was reported most frequently (31%) as the underlying disease. Among patients younger than 40 years, steroid use was the most prominent potential causative factor (60%), and hip replacement frequently was performed (45%). A greater proportion of patients with no history of steroid or alcohol use was observed among patients 65 years or older (41%). In addition to the disease burden of idiopathic ONFH in Japan, our results confirmed the importance of developing preventive and treatment strategies, especially among the younger population. Level IV, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.
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DOI：
10.1302/0301-620x.81b4.9393
发表时间：
1999-07-01
影响因子：
--
作者：
Sugano, N;Kubo, T;Ninomiya, S
通讯作者：
Ninomiya, S
DOI：
10.1007/s007760200108
发表时间：
2002-01-01
期刊：
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
影响因子：
--
作者：
Sugano, Nobuhiko;Atsumi, Takashi;Takaoka, Kunio
通讯作者：
Takaoka, Kunio
DOI：
10.1097/01.blo.0000137238.02035.c2
发表时间：
2004-08-01
影响因子：
4.2
作者：
Björkman, A;Svensson, PJ;Benoni, G
通讯作者：
Benoni, G
DOI：
10.2106/00004623-199906000-00006
发表时间：
1999-06-01
影响因子：
5.3
作者：
Montella, BJ;Nunley, JA;Urbaniak, JR
通讯作者：
Urbaniak, JR
影响因子：
2.8
作者：
Koo, Kyung-Hoi;Lee, Jong Seok;Kim, Hee Joong
通讯作者：
Kim, Hee Joong