Histopathologic examination of the rat nasal cavity.
Histopathologic examination of the rat nasal cavity.
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DOI：
10.1016/s0272-0590(81)80037-1
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发表时间：
1981-07-01
期刊：
影响因子：
--
通讯作者：
Young, J T
中科院分区：
文献类型：
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作者：
Young, J T
本文介绍了一种用于组织病理学检查的大鼠鼻腔标本的制备方法，并描述了所得切片的解剖学特征。该方法产生四个组织切片，选择这些组织切片是因为它们的可重复性基于口腔背面的标志，并且因为每个切片的解剖特征有助于鼻腔的彻底检查。检查的四个区域包括在以下点获取的横切面：（1）上切牙紧后方，（2）切牙乳头，（3）第二腭嵴，（4）第一上臼齿水平。本文还讨论了各切面对鼻腔及邻近结构的整体评价价值。所述方法适用于短期和慢性毒性研究，并允许在尸检时对鼻腔进行彻底检查，而不会造成破坏性侵入。
A method for preparation of the rat nasal cavity for histopathologic examination is presented, and the anatomic features of the sections obtained are described. The method results in four tissue sections which are selected because of their reproducibility based on landmarks on the dorsal aspect of the mouth and because of the anatomic features of each section which contribute to a thorough examination of the nasal cavity. The four areas examined include transverse sections taken at the following points: (1) immediately posterior to the upper incisor teeth, (2) at the incisive papilla, (3) at the second palatal ridge, and (4) at the level of the first upper molar teeth. The value of each section to the overall evaluation of the nasal cavity and adjacent structures is also discussed. The method described is applicable to both short-term and chronic toxicity studies, and allows for a thorough examination of the nasal cavity without destructive invasion at the time of necropsy.