TMS Brain Mapping in Less Than Two Minutes
TMS Brain Mapping in Less Than Two Minutes
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DOI：
10.1016/j.brs.2014.10.020
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发表时间：
2015-03-01
影响因子：
7.7
通讯作者：
Grey, Michael J.
中科院分区：
文献类型：
--
作者：
van de Ruit, Mark;Perenboom, Matthijs J. L.;Grey, Michael J.
背景：经颅磁刺激（TMS）皮质脊髓兴奋性图是研究皮质脊髓束可塑性的重要工具。传统上，单一图谱的数据采集非常耗时，限制了该方法在兴奋性快速变化时的适用性，例如在运动学习期间，以及在评估时间是限制因素的临床研究中。目的：通过研究刺激可能传递的最小刺激间间隔（ISI）和研究创建地图所需的最小刺激数来减少创建可靠地图所需的时间。方法：当线圈在6 × 6 cm的正方形内伪随机移动时，采用无框立体定位法监测线圈位置。在12名参与者中使用1-4 s ISIs获取地图。通过随机提取数据并将结果图与原始数据集进行比较，确定最小刺激数。为了验证伪随机漫步方法的有效性，将其与传统的映射方法进行了比较。结果：用1 s ISI记录了63个刺激，形成了可靠的图谱。采用伪随机漫步法获取数据生成的地图与采用传统方法获取的地图没有显著差异。结论：为了考虑参与者之间的差异、异常值、线圈定位误差，以及最重要的参与者在数据采集过程中的舒适度，我们建议创建一个包含80个刺激和1.5 s ISI的地图。这使得在2分钟内获得经颅磁刺激图谱成为可能，使图谱成为研究皮层组织短期和长期变化的更可行的工具。(C) 2015爱思唯尔公司版权所有。
Background: Transcranial magnetic stimulation (TMS) corticospinal excitability maps are a valuable tool to study plasticity in the corticospinal tract. Traditionally, data acquisition for a single map is time consuming, limiting the method's applicability when excitability changes quickly, such as during motor learning, and in clinical investigations where assessment time is a limiting factor.Objective: To reduce the time needed to create a reliable map by 1) investigating the minimum inter-stimulus interval (ISI) at which stimuli may be delivered, and 2) investigating the minimum number of stimuli required to create a map.Method: Frameless stereotaxy was used to monitor coil position as the coil was moved pseudorandomly within a 6 x 6 cm square. Maps were acquired using 1-4 s ISIs in 12 participants. The minimum number of stimuli was determined by randomly extracting data and comparing the resulting map to the original data set. To confirm validity, the pseudorandom walk method was compared against a traditional mapping method.Results: Reliable maps could be created with 63 stimuli recorded with a 1 s ISI. Maps created acquiring data using the pseudorandom walk method were not significantly different from maps acquired following the traditional method.Conclusions: To account for inter-participant variability, outliers, coil positioning errors and, most importantly, participant comfort during data acquisition, we recommend creating a map with 80 stimuli and a 1.5 s ISI. This makes it possible to acquire TMS maps in 2 min, making mapping a more feasible tool to study short-and long-term changes in cortical organization. (C) 2015 Elsevier Inc. All rights reserved.