Hepatobiliary enhancement with Gd-EOB-DTPA: comparison of spin-echo and STIR imaging for detection of experimental liver metastases.
Hepatobiliary enhancement with Gd-EOB-DTPA: comparison of spin-echo and STIR imaging for detection of experimental liver metastases.
复制标题
Gd-EOB-DTPA 肝胆增强：自旋回波和 STIR 成像检测实验性肝转移的比较。
DOI：
10.1148/radiology.184.1.1609081
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发表时间：
1992
期刊：
影响因子：
19.7
通讯作者：
Brasch,RC
中科院分区：
文献类型：
--
作者：
Muhler,A;Clement,O;Vexler,V;Berthezene,Y;Rosenau,W;Brasch,RC
（4S）-4-（4-乙氧基苄基）-3，6，9-三（羧甲基）-3，6，9-三氮杂十一烷二酸二钠盐（EOB-DTPA）乙氧基苄基钆是一种新型的肝胆磁共振（MR）造影剂，具有双重消除作用：在正常大鼠中75%通过肝脏和胆汁，25%通过肾脏。在这项研究中，Gd-EOB-DTPA在转移性肝脏疾病的啮齿动物模型中进行了评估，以测量相对增强和病变与肝脏对比度。第二个目标是比较自旋回波（SE）和短反转时间反转恢复（STIR）成像的相对性能，以证明Gd-EOB-DTPA的增强。每公斤注射0.1 mmol Gd-EOB-DTPA后，使用SE技术，肝脏信号增加（阳性增强）超过200%，使用STIR技术，肝脏信号下降（阴性增强）超过80%。仅观察到植入的肝肿瘤的最小增强。与肿瘤不同，胆囊和十二指肠腔随着时间的推移逐渐增强。Gd-EOB-DTPA给药后，SE和STIR技术的病变与肝脏对比度增加约500%。
Gadolinium (4S)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9- triazaundecandioic acid-disodium salt (EOB-DTPA) ethoxybenzyl is a new hepatobiliary magnetic resonance (MR) contrast agent with dual elimination: 75% through the liver and bile and 25% through the kidneys in normal rats. In this study, Gd-EOB-DTPA was evaluated in a rodent model of metastatic liver disease to measure both relative enhancement and lesion-to-liver contrast. A secondary goal was to compare the relative performance of spin-echo (SE) and short inversion time inversion-recovery (STIR) imaging to demonstrate enhancement with Gd-EOB-DTPA. After administration of 0.1 mmol of Gd-EOB-DTPA per kilogram, liver signal increased (positive enhancement) more than 200% with the use of the SE technique and declined (negative enhancement) by more than 80% with use of the STIR technique. Only minimal enhancement of implanted liver tumor was observed. Unlike the tumor, the gall-bladder and lumen of the duodenum were progressively enhanced over time. The lesion-to-liver contrast increased by approximately 500% with both the SE and STIR techniques after administration of Gd-EOB-DTPA.