FINE STRUCTURE OF TASTE BUD
FINE STRUCTURE OF TASTE BUD
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DOI：
10.1016/s0022-5320(65)80103-4
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发表时间：
1965-01-01
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影响因子：
--
通讯作者：
FARBMAN, AI
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文献类型：
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作者：
FARBMAN, AI
对成年大鼠舌头菌状乳头的味蕾进行了电子显微镜研究。描述了四种细胞类型，根据其位置、形态以及与上皮内神经过程的关系进行分类。这些是外周细胞、基底细胞、I 型（深色）和 II 型（浅色）细胞。外周细胞位于味蕾下半部的外周。它们的主要特征是其高含量的弥散分散的 RNP 颗粒、其特征性的管状细丝以及它们与上皮内神经过程缺乏关联。外周细胞被认为是味蕾中所有其他细胞类型的前体。基底细胞位于味蕾中央区域的下极附近。它们靠近一个或多个神经过程。基底细胞在形态上与外周细胞相似，只是它们具有更广泛的高尔基体，并且在邻近神经突的细胞质区域中具有一簇小囊泡。这种细胞类型被认为是外周细胞与I型和II型细胞之间的中间形式。囊泡簇被认为代表了这种中间细胞类型早期分化变化的证据。 I型细胞呈纺锤形，从基底膜延伸至味孔。微绒毛从这种细胞类型的顶端部分突出到毛孔中。细胞质具有以下特征： 丰富的细腻丝状物质；层状致密体；一个突出的高尔基体，但其他细胞器很少。邻近的 I 型细胞在其远端附近形成紧密连接。这种细胞类型通常以与雪旺细胞类似的方式包裹多个上皮内神经突。 I型细胞被认为是味觉受体细胞。 II 型细胞的细胞质的特点是含有丰富的线粒体和不同大小的囊泡和液泡。据推测，该细胞在味孔的形成和维持中发挥作用。味孔通常被无定形致密物质堵塞，其中含有数个小的、膜结合的囊泡，推测是细胞起源的。
An electron microscope study on the taste bud in the fungiform papilla of the adult rat tongue was performed. Four cell types, classified according to their location, morphology, and relation to intraepithelial nerve processes, are described. These are the peripheral, basal, type I (dark), and type II (light) cells. The peripheral cells are located on the outer circumference of the lower half of the taste bud. They are characterized primarily by their high content of diffusely scattered RNP particles, their characteristic tubular filaments, and their lack of association with intraepithelial nerve processes. Peripheral cells are considered to be the precursors of all the other cell types in the taste bud. Basal cells are located near the inferior pole of the central area of the taste bud. They are in proximity to one or more nerve processes. The basal cells are similar morphologically to peripheral cells except that they have a more extensive Golgi apparatus and, in that area of their cytoplasm adjacent to a nerve process, a cluster of small vesicles. This cell type is considered to be an intermediate form between peripheral cells and the type I and type II cells. The cluster of vesicles is thought to represent evidence for early differentiative changes in this intermediate cell type. Type I cells are spindle-shaped and extend from the basement membrane to the taste pore. Microvilli project from the apical part of this cell type into the pore. The cytoplasm is characterized by the following: an abundance of delicate, filamentous material; lamellated, dense bodies; a prominent Golgi apparatus, but few other organelles. Tight junctions are formed between adjacent type I cells near their distal ends. This cell type usually envelops several intraepithelial nerve processes in a manner similar to that of Schwann cells. The type I cell is considered to be a taste receptor cell. The type II cell cytoplasm is characterized by an abundance of mitochondria and variously sized vesicles and vacuoles. It is proposed that this cell plays a role in formation and maintenance of the taste pore. The taste pore is usually plugged with amorphous dense material containing several, small, membrane-bounded vesicles, presumably of cellular origin.