The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila.
The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila.
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DOI：
10.1038/srep11680
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发表时间：
2015-06-30
影响因子：
4.6
通讯作者：
Rewitz KF
中科院分区：
文献类型：
--
作者：
Hentze JL;Carlsson MA;Kondo S;Nässel DR;Rewitz KF
协调新陈代谢和进食对于避免肥胖和代谢性疾病很重要，但平衡营养摄入和代谢支出的潜在机制却知之甚少。控制这些过程的几种机制在果蝇中是保守的，其中稳态和能量动员受高血糖素相关脂肪运动激素(AKH)和果蝇胰岛素样肽(DILPs)的调节。在这里，我们提供了果蝇神经肽Allatostatin A(ASTA)调节AKH和DILP信号的证据。AstA受体基因DAR-2在胰岛素和AKH产生细胞中都有表达。在这些细胞中沉默DAR-2导致基因表达和生理变化，与DILP和AKH信号减少相关，缺乏ASTA的动物积累高脂水平。这表明ASA正在调节DILP和AKH之间的平衡，这被认为对于维持营养动态平衡是重要的，以应对饮食中糖和蛋白质比例的变化。此外，Asta和DAR-2受膳食碳水化合物和蛋白质的不同调节，Asta神经元的活动调节这些类型的营养物质之间的摄食选择。我们的结果表明，ASA参与了对这些营养物质的赋值，以协调代谢和喂养决策，这些反应对于根据代谢需求平衡食物摄入量非常重要。
Coordinating metabolism and feeding is important to avoid obesity and metabolic diseases, yet the underlying mechanisms, balancing nutrient intake and metabolic expenditure, are poorly understood. Several mechanisms controlling these processes are conserved in Drosophila, where homeostasis and energy mobilization are regulated by the glucagon-related adipokinetic hormone (AKH) and the Drosophila insulin-like peptides (DILPs). Here, we provide evidence that the Drosophila neuropeptide Allatostatin A (AstA) regulates AKH and DILP signaling. The AstA receptor gene, Dar-2, is expressed in both the insulin and AKH producing cells. Silencing of Dar-2 in these cells results in changes in gene expression and physiology associated with reduced DILP and AKH signaling and animals lacking AstA accumulate high lipid levels. This suggests that AstA is regulating the balance between DILP and AKH, believed to be important for the maintenance of nutrient homeostasis in response to changing ratios of dietary sugar and protein. Furthermore, AstA and Dar-2 are regulated differentially by dietary carbohydrates and protein and AstA-neuronal activity modulates feeding choices between these types of nutrients. Our results suggest that AstA is involved in assigning value to these nutrients to coordinate metabolic and feeding decisions, responses that are important to balance food intake according to metabolic needs.
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影响因子：
9.8
作者：
Grönke S;Müller G;Hirsch J;Fellert S;Andreou A;Haase T;Jäckle H;Kühnlein RP
通讯作者：
Kühnlein RP
影响因子：
9.2
作者：
Brogiolo, W;Stocker, H;Hafen, E
通讯作者：
Hafen, E
影响因子：
4.5
作者：
Danielsen ET;Moeller ME;Dorry E;Komura-Kawa T;Fujimoto Y;Troelsen JT;Herder R;O'Connor MB;Niwa R;Rewitz KF
通讯作者：
Rewitz KF
影响因子：
7.7
作者：
FELIG, P;WAHREN, J;HENDLER, R
通讯作者：
HENDLER, R
DOI：
10.1242/jeb.016451
发表时间：
2008-10
期刊：
The Journal of experimental biology
影响因子：
--
作者：
Bharucha KN;Tarr P;Zipursky SL
通讯作者：
Zipursky SL