Peptide growth factors in normal and hypertrophied bladder.
Peptide growth factors in normal and hypertrophied bladder.
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正常和肥大膀胱中的肽生长因子。
DOI：
10.1007/bf00191215
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发表时间：
1995
影响因子：
3.4
通讯作者：
Buttyan,R
中科院分区：
文献类型：
--
作者：
Chen,MW;Levin,RM;Buttyan,R
膀胱是一个动态器官，通过迅速增加质量和细胞含量来补偿尿道阻力的增加，从而对出口阻塞的压力作出反应。如果在失代偿之前释放出口阻塞，肥大的膀胱将收缩，恢复到正常的大小和细胞结构。然而，慢性梗阻会使膀胱体积继续增大，细胞外基质的数量和组成发生剧烈变化，最终丧失功能。与这些变化相关的广泛的组织重塑需要不同的膀胱成分经历细胞增殖、细胞肥大，甚至程序性细胞死亡（凋亡）。这些细胞过程中的每一个都是由被称为生长因子的各种多肽调节的。在此，我们概述了已知的影响膀胱的生长因子，以及各种实验动物研究，这些研究推测出四种特定的生长因子[碱性成纤维细胞生长因子（bFGF），转化生长因子-β (TGF-β)，神经生长因子（NGF）和表皮生长因子（EGF）]在梗阻性膀胱反应中的作用。
The bladder is a dynamic organ that responds to the stress of outlet obstruction by rapidly increasing in mass and cellular content to compensate for increased urethral resistance. If the outlet obstruction is released prior to decompensation, the hypertrophied bladder will shrink, returning to normal size and cellularity. However, with chronic obstruction the bladder will continue to increase in mass, developing drastic alterations in the amount and composition of the extracellular matrix and, ultimately, losing the ability to function. The extensive tissue remodeling associated with each of these changes requires different bladder components to undergo cellular proliferation, cellular hypertrophy, and even programmed cell death (apoptosis). Each of these cellular processes is known to be regulated by various peptides that are referred to as growth factors. Herein we provide an overview of the growth factors that are known to influence the bladder in addition to a variety of experimental animal studies that putatively identify a role of four particular growth factors [basic fibroblast growth factor (bFGF), transforming growth factor-β (TGF-β), nerve growth factor (NGF), and epidermal growth factor (EGF)] in the obstructive bladder response.