Genomic scans reveal multiple mito-nuclear incompatibilities in population crosses of the copepod Tigriopus californicus
Genomic scans reveal multiple mito-nuclear incompatibilities in population crosses of the copepod Tigriopus californicus
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DOI：
10.1111/evo.13690
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发表时间：
2019-03-01
期刊：
影响因子：
3.3
通讯作者：
Willett, Christopher S.
中科院分区：
文献类型：
--
作者：
Lima, Thiago G.;Burton, Ronald S.;Willett, Christopher S.
内在合子后隔离的进化可以用多布赞斯基-穆勒不亲和性的积累来解释。在正反交之间通常观察到杂种不育性和杂种无活力水平的不对称性，这种模式可能是单亲遗传因素的参与所致。线粒体基因组就是这样一个因素，似乎参与了一些杂交中的遗传，但其参与的频率与双亲遗传因素尚不清楚。在这里，我们评估核因子（核-核）与线粒体和核因子（线粒体-核）之间的不相容性在一个缺乏性染色体的物种中的相对重要性。我们使用了Pool-Seq的方法来调查三个交叉之间的桡足类，Tigriopus californicus，基因组的区域，受混合活力的遗传分歧的人口。从正反交的结果表明，有丝分裂核不相容性比核核不相容性更普遍的整体。这些结果表明，在线粒体DNA单倍型之间存在非常高水平的核苷酸分歧，线粒体核不相容性可能是重要的内在合子后隔离的演变。这是特别有趣的考虑到这个物种缺乏性染色体，这已被证明在其他几个物种中含有特别高数量的核-核双染色体。
The evolution of intrinsic postzygotic isolation can be explained by the accumulation of Dobzhansky-Muller incompatibilities (DMI). Asymmetries in the levels of hybrid inviability and hybrid sterility are commonly observed between reciprocal crosses, a pattern that can result from the involvement of uniparentally inherited factors. The mitochondrial genome is one such factor that appears to participate in DMI in some crosses but the frequency of its involvement versus biparentally inherited factors is unclear. Here we assess the relative importance of incompatibilities between nuclear factors (nuclear-nuclear) versus those between mitochondrial and nuclear factors (mito-nuclear) in a species that lacks sex chromosomes. We used a Pool-seq approach to survey three crosses among genetically divergent populations of the copepod, Tigriopus californicus, for regions of the genome that are affected by hybrid inviability. Results from reciprocal crosses suggest that mito-nuclear incompatibilities are more common than nuclear-nuclear incompatibilities overall. These results suggest that in the presence of very high levels of nucleotide divergence between mtDNA haplotypes, mito-nuclear incompatibilities can be important for the evolution of intrinsic postzygotic isolation. This is particularly interesting considering this species lacks sex chromosomes, which have been shown to harbor a particularly high number of nuclear-nuclear DMI in several other species.