EFFECTS OF 2 KINDS OF CHICKEN LUTEINIZING-HORMONE-RELEASING HORMONE (LH-RH), MAMMALIAN LH-RH AND ITS ANALOGS ON THE RELEASE OF LH AND FSH IN JAPANESE-QUAIL AND CHICKEN
EFFECTS OF 2 KINDS OF CHICKEN LUTEINIZING-HORMONE-RELEASING HORMONE (LH-RH), MAMMALIAN LH-RH AND ITS ANALOGS ON THE RELEASE OF LH AND FSH IN JAPANESE-QUAIL AND CHICKEN
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DOI：
10.1016/0016-6480(86)90082-1
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发表时间：
1986-12-01
影响因子：
2.7
通讯作者：
WADA, M
中科院分区：
文献类型：
--
作者：
HATTORI, A;ISHII, S;WADA, M
新分离鉴定的鸡黄体生成素释放激素- ii（鸡LH-RH-II）。Miyamoto et al., 1984)在日本鹌鹑体内体外有促黄体生成素（LH）和促卵泡激素（FSH）释放活性；活性与鸡的LH-RH- i和哺乳动物的LH-RH基本相当。在体外和体内，这三种LH- rhs诱导的LH释放量比FSH高数倍。鸡LH- rh - i和LH- rh - ii在相同孵育条件下用鸡脑垂体体外释放LH的活性与鹌鹑无显著差异。另一项实验表明，鸡的LH- rh - i和-II之间不存在协同作用，[D-Phe2, Pro3， D-Phe6]-LH-RH和中催产素均无LH和FSH释放活性。然而，在哺乳动物的超活性类似物[D-Ala6， des-Gly10]-LH-RH乙胺中观察到与鸡的LH-RH-II相同的效力。结果表明，鸟类腺垂体与哺乳动物腺垂体对rh分子的反应不同，这表明鸟类的rh受体对rh分子的“识别”特异性可能低于哺乳动物的rh受体。
A newly isolated and characterized chicken luteinizing hormone-releasing hormone-II (chicken LH-RH-II. Miyamoto et al., 1984) had luteinizing hormone (LH) and follicle-stimulating hormone (FSH) releasing activity in vitro and in vivo in Japanese quail; the activity was almost equal to chicken LH-RH-I and mammalian LH-RH. These three LH-RHs induced the release of LH several times higher than that of FSH in vitro and also in vivo. No significant difference between chicken LH-RH-I and LH-RH-II was observed in LH releasing activity in vitro using chicken pituitary gland in the same incubating condition as in quail. Another experiment indicated that no synergism existed between chicken LH-RH-I and -II and that there was neither LH nor FSH releasing activity in [D-Phe2, Pro3, D-Phe6]-LH-RH or in mesotocin. However, the same potency as in the chicken LH-RH-II was observed in [D-Ala6, des-Gly10]-LH-RH ethylamide, a superactive analog in mammals. The results indicate that an avian adenohypophysis differs from a mammalian adenohypophysis in its responsiveness to LH-RH suggesting that an avian LH-RH receptor may have a lower specificity in "recognition" of LH-RH molecules than a mammalian LH-RH receptor has.