Hepatocellular carcinoma: evaluation with dynamic and static gadobenate dimeglumine-enhanced MR imaging and histopathologic correlation.
Hepatocellular carcinoma: evaluation with dynamic and static gadobenate dimeglumine-enhanced MR imaging and histopathologic correlation.
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DOI：
10.1148/radiology.205.3.9393527
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发表时间：
1997-12
期刊：
影响因子：
19.7
通讯作者：
T. Vogl;A. Stupavsky;W. Pegios;R. Hammerstingl;M. Mack;T. Diebold;K. Lodemann;P. Neuhaus;R. Felix
中科院分区：
文献类型：
--
作者：
T. Vogl;A. Stupavsky;W. Pegios;R. Hammerstingl;M. Mack;T. Diebold;K. Lodemann;P. Neuhaus;R. Felix
目的分析加多贝酯双葡胺增强磁共振(MR)静态序列和动态序列在肝细胞癌(HCC)定性诊断中的应用价值。资料与方法2 8例经手术病理证实的肝细胞癌患者，分别于静脉注射0.1m ol/kg加多贝酸地葡胺(0.5m o l/L)前、中、后分别行T1、T2加权自旋回波序列及静态和动态梯度回波序列检查。结果在动态序列的灌注期，16个高分化结节状肝细胞癌病灶在注射后10~30s信号迅速增强，然后逐渐降低。9个低分化肝细胞癌病灶的信号强度均未见明显增加。与正常肝实质相比，所有8个大的(>；3厘米)结节状、分化良好的肝细胞癌病灶在注射前均表现为低信号的边缘，注射后立即显示低信号和高信号的边缘(双环征)。注射后约55秒，在28个肝细胞癌病灶中的21个病灶检测到明显的单环强化。结论动态增强扫描可改善肝细胞癌病变的定性，在分化较好的肝细胞癌病变的早期动脉期信号迅速增强，在分化较大的结节状肝细胞癌病变中表现为双环征。
PURPOSE To analyze the potential of gadobenate dimeglumine-enhanced magnetic resonance (MR) imaging for the characterization and diagnosis of hepatocellular carcinoma (HCC) by using static and dynamic sequences. MATERIALS AND METHODS Twenty-eight patients with histopathologically proved HCC were evaluated with T1- and T2-weighted spin-echo and static and dynamic gradient-echo sequences before, during, and after intravenous administration of 0.1 mmol/kg gadobenate dimeglumine (0.5 mol/L). RESULTS During the perfusion phase of the dynamic sequence, all 16 nodular well-differentiated HCC lesions showed a rapid increase in signal intensity 10-30 seconds after injection followed by a progressive decrease in signal intensity. The nine poorly differentiated HCC lesions showed no rapid increase in signal intensity. All eight large (> 3 cm), nodular, well-differentiated HCC lesions showed a hypointense rim before injection and both hypo- and hyperintense rims (double-ring sign) immediately after injection, compared with normal liver parenchyma. About 55 seconds after injection, substantial single-rim enhancement was detected in 21 of the 28 HCC lesions. CONCLUSION Dynamic gadobenate dimeglumine-enhanced MR imaging allows improved characterization of HCC lesions, which show rapid increase in signal intensity during the early, arterial phase in well-differentiated HCC lesions and a double-ring sign in large well-differentiated nodular HCC lesions.