MicroRNA-133b expression inversely correlates with MET and can serve as an optimum predictive biomarker for patients of colorectal cancer.
MicroRNA-133b expression inversely correlates with MET and can serve as an optimum predictive biomarker for patients of colorectal cancer.
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MicroRNA-133b 表达与 MET 呈负相关，可作为结直肠癌患者的最佳预测生物标志物
DOI：
10.21037/tcr-20-2370
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发表时间：
2021-01
影响因子：
0.9
通讯作者：
Hu G
中科院分区：
文献类型：
--
作者：
Xie B;Gong N;Guo Y;Hu G
背景肿瘤抑制基因microRNA-133 b的失活是包括结直肠癌（CRC）在内的各种恶性肿瘤中的常见事件。我们前期的研究结果发现microRNA-133 b在人结直肠癌细胞中的表达显著下调，microRNA-133 b可以通过靶向和抑制间充质上皮转化因子在体外和体内阻断结直肠癌细胞的生长和转移进展。在这项研究中，我们确定microRNA-133 b，上皮转化因子表达和临床病理参数之间的关联。方法检测46例结直肠癌组织中microRNA-133 b和上皮转移因子（epithelial transitioning factor，ETF）的基因和蛋白表达。评估microRNA-133 b、上皮转化因子与结直肠癌相关临床病理参数之间的相关性。此外，还评估了microRNA-133 b和上皮转化因子在CRC中的诊断能力。结果大肠癌组织中microRNA-133 b表达降低，癌基因上皮转化因子的表达与microRNA-133 b的表达呈极强的负相关。我们还观察到microRNA-133 b和上皮转化因子的表达水平与CRC组织的临床分期和淋巴结转移有统计学相关性，并且进一步鉴定的microRNA-133 b和/或上皮转化因子可能有助于通过受试者工作特征（ROC）曲线分析来区分CRC患者和正常人群。结论microRNA-133 b表达与上皮转化因子表达呈负相关。microRNA-133 b和/或上皮转化因子可能是有用的CRC患者的有价值的预后生物标志物。
Background Inactivation of the tumor suppressor gene microRNA-133b is a frequent event in various malignancies including colorectal cancer (CRC). The result of our previous research has found a statistically significant downregulation of microRNA-133b expression in human CRC cells, microRNA-133b can block the growth and metastatic progression of CRC cells in vitro and in vivo by targeting and repressing mesenchymal to epithelial transition factor. In this study, we identify the association between microRNA-133b, epithelial transition factor expression and clinicopathological parameters. Methods The detection of microRNA-133b and epithelial transition factor between gene and protein expression was evaluated in 46 patients with CRC. The correlation among microRNA-133b, epithelial transition factor and clinicopathological parameters associated with CRC was assessed. Furthermore, the diagnostic capability of microRNA-133b and epithelial transition factor in CRC was also evaluated. Results The results show decreased microRNA-133b expression in CRC tissues, and a very strong inverse correlation between the expression of oncogene epithelial transition factor and the expression of microRNA-133b. We also observed that the expression levels of microRNA-133b and epithelial transition factor were statistical associated with clinical stage and lymph node metastasis in CRC tissues, and further identified microRNA-133b and/or epithelial transition factor may be useful for distinguishing CRC patients from the normal population by receiver operating characteristic (ROC) curve analysis. Conclusions microRNA-133b expression is inversely correlated with epithelial transition factor expression. MicroRNA-133b and/or epithelial transition factor may be useful as valuable prognostic biomarkers in CRC patients.
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DOI：
10.1073/pnas.1005183107
发表时间：
2010-07-27
影响因子：
11.1
作者：
Tolbert, W. David;Daugherty-Holtrop, Jennifer;Xu, H. Eric
通讯作者：
Xu, H. Eric
影响因子：
3.1
作者：
Li H;Xiang Z;Liu Y;Xu B;Tang J
通讯作者：
Tang J
MicroRNA-217 可作为预后预测因子，并通过 AEG-1 依赖性机制抑制结直肠癌细胞增殖和侵袭
影响因子：
3.8
作者：
Wang B;Shen ZL;Jiang KW;Zhao G;Wang CY;Yan YC;Yang Y;Zhang JZ;Shen C;Gao ZD;Ye YJ;Wang S
通讯作者：
Wang S
影响因子：
--
作者：
Cao ZG;Li JJ;Yao L;Huang YN;Liu YR;Hu X;Song CG;Shao ZM
通讯作者：
Shao ZM
影响因子：
5.5
作者：
Pal MK;Jaiswar SP;Dwivedi VN;Tripathi AK;Dwivedi A;Sankhwar P
通讯作者：
Sankhwar P